X0508 4 2023-08-01 0 0001178879 AMICUS THERAPEUTICS, INC. FOLD 0001400973 Crowley John F C/O AMICUS THERAPEUTICS, INC. 3675 MARKET STREET PHILADELPHIA PA 19104 1 1 0 0 Executive Chairman 1 Common Stock 2023-08-01 4 S 0 6044 13.3548 D 932141 D Common Stock 64895 I By Trust This price is the weighted average price for the transactions reported on this line. The prices for the transactions reported on this line range from $13.22 to $13.48 inclusive. The reporting person undertakes to provide, upon request, by the staff of the Securities and Exchange Commission, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. All transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 7, 2022. In addition to the reported transactions, Mr. Crowley also has approximately 746,000 options outstanding and exercisable at various strike prices. /s/ Christian Formica, Attorney-in-Fact 2023-08-03