X0306 4 2021-12-31 0 0001178879 AMICUS THERAPEUTICS, INC. FOLD 0001400973 Crowley John F C/O AMICUS THERAPEUTICS, INC. 3675 MARKET STREET PHILADELPHIA PA 19104 1 1 0 0 Chairman & CEO Common Stock 2021-12-31 4 F 0 31479 11.55 D 793047 D Common Stock 2022-01-02 4 F 0 22968 11.55 D 770079 D Common Stock 2022-01-03 4 F 0 40069 12.11 D 730010 D Common Stock 2022-01-04 4 F 0 11336 12.48 D 718674 D Common Stock 64895 I By Trust /s/ Christian Formica, Attorney-in-Fact 2022-01-04