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Stockholders' Equity (Details 3) (USD $)
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Dec. 31, 2014
Stockholders' Equity      
Equity compensation expense $ 1,960,000us-gaap_AllocatedShareBasedCompensationExpense $ 1,260,000us-gaap_AllocatedShareBasedCompensationExpense  
Fair value weighted-average assumptions:      
Expected life of options 5 months 27 days    
Aggregate Intrinsic Value      
Unrecognized compensation cost related to unvested restricted stock awards (in dollars) 700,000us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions    
Nonqualified Cash Plan      
Stockholders' Equity      
Deferred compensation liability, noncurrent 400,000us-gaap_DeferredCompensationLiabilityClassifiedNoncurrent
/ us-gaap_PlanNameAxis
= fold_NonqualifiedCashPlanMember
  100,000us-gaap_DeferredCompensationLiabilityClassifiedNoncurrent
/ us-gaap_PlanNameAxis
= fold_NonqualifiedCashPlanMember
Trading securities 400,000us-gaap_TradingSecurities
/ us-gaap_PlanNameAxis
= fold_NonqualifiedCashPlanMember
   
Common stock options      
Stockholders' Equity      
Total unrecognized compensation cost related to non-vested stock options granted (in dollars) 13,400,000us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Period of recognition compensation cost 3 years    
Fair value weighted-average assumptions:      
Expected stock price volatility (as a percent) 77.10%us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
81.40%us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
 
Risk free interest rate (as a percent) 1.70%us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
2.00%us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
 
Expected life of options 6 years 3 months 6 years 3 months  
Expected annual dividend per share (in dollars per share) $ 0.00fold_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPerShare
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
$ 0.00fold_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendPerShare
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
 
Number of Shares      
Balance at the beginning of the period (in shares) 10,020,700us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Options granted (in shares) 1,415,700us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Options exercised (in shares) (818,700)us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Options forfeited (in shares) (15,000)us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Balance at the end of the period (in shares) 10,602,700us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Vested and unvested expected to vest at the end of the period (in shares) 9,842,500us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Exercisable at the end of the period (in shares) 5,261,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Weighted Average Exercise Price      
Balance at the beginning of the period (in dollars per share) $ 5.02us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Options granted (in dollars per share) $ 9.07us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Options exercised (in dollars per share) $ 5.02us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Options forfeited (in dollars per share) $ 2.80us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Balance at the end of the period (in dollars per share) $ 5.56us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Vested and unvested expected to vest at the end of the period (in dollars per share) $ 5.58us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Exercisable at the end of the period (in dollars per share) $ 6.30us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Weighted Average Remaining Contractual Life      
Balance at the end of the period 7 years 3 months 18 days    
Vested and unvested expected to vest at the end of the period 7 years 2 months 12 days    
Exercisable at the end of the period 5 years 8 months 12 days    
Aggregate Intrinsic Value      
Aggregate intrinsic value of options outstanding (in dollars) 57,600us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Aggregate intrinsic value of options vested and unvested expected to vest (in dollars) 53,400us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Aggregate intrinsic value of options exercisable (in dollars) 25,300us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1
/ us-gaap_AwardTypeAxis
= fold_EmployeeAndDirectorsStockOptionsMember
   
Restricted stock units (RSUs)      
Stockholders' Equity      
Period of recognition compensation cost 5 months 27 days    
Number of Shares      
Balance at the beginning of the period (in shares) 955,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_AwardTypeAxis
= us-gaap_RestrictedStockUnitsRSUMember
   
Balance at the end of the period (in shares) 955,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
/ us-gaap_AwardTypeAxis
= us-gaap_RestrictedStockUnitsRSUMember
   
Weighted Average Exercise Price      
Balance at the beginning of the period (in dollars per share) $ 2.28us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_RestrictedStockUnitsRSUMember
   
Balance at the end of the period (in dollars per share) $ 2.28us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
/ us-gaap_AwardTypeAxis
= us-gaap_RestrictedStockUnitsRSUMember
   
Aggregate Intrinsic Value      
Aggregate intrinsic value, nonvested (in dollars) 8,200,000us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueNonvested
/ us-gaap_AwardTypeAxis
= us-gaap_RestrictedStockUnitsRSUMember
   
Options vested 0us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedNumberOfShares
/ us-gaap_AwardTypeAxis
= us-gaap_RestrictedStockUnitsRSUMember
   
Maximum | Nonqualified Cash Plan      
Stockholders' Equity      
Income from investments 1,000us-gaap_TradingSecuritiesRealizedGainLoss
/ us-gaap_PlanNameAxis
= fold_NonqualifiedCashPlanMember
/ us-gaap_RangeAxis
= us-gaap_MaximumMember
   
Unrealized gain/loss $ 1,000us-gaap_TradingSecuritiesUnrealizedHoldingGainLoss
/ us-gaap_PlanNameAxis
= fold_NonqualifiedCashPlanMember
/ us-gaap_RangeAxis
= us-gaap_MaximumMember