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Stockholder's Equity (Details 2) (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2013	Mar. 31, 2012
Stock compensation expense
Total stock compensation expense	$ 1,574	$ 1,388
Research and development expense
Stock compensation expense
Total stock compensation expense	924	873
General and administrative expense
Stock compensation expense
Total stock compensation expense	$ 650	$ 515

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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