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Warrants (Details 1) - Warrant [Member] - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Number of Warrants      
Outstanding - Beginning Balance 183,737 134,209  
Exercisable - Beginning Balance 171,237 104,209  
Granted 2,050,000 60,000  
Forfeited or Expired (1,237) (10,472)  
Outstanding - Ending Balance 2,232,500 183,737 134,209
Exercisable - Ending Balance 2,232,500 171,237 104,209
Weighted Average Exercise Price per Share      
Outstanding - Beginning Balance $ 7.35 $ 23.87  
Exercisable - Beginning Balance 7.15 27.87  
Granted 1.00 2.91  
Forfeited or Expired 303.37 193.72  
Outstanding - Ending Balance 1.36 7.35 $ 23.87
Exercisable- Ending Balance $ 1.36 $ 7.15 $ 27.87
Weighted Average Remaining Contractual Life in Years, Outstanding 4 years 4 months 2 days 2 years 8 months 12 days 3 years 7 months 28 days
Weighted Average Remaining Contractual Life in Years, Exercisable 4 years 4 months 2 days 2 years 9 months 14 days 4 years 4 days
Aggregate Intrinsic Value Exercisable $ 0 $ 0 $ 0