Summary of Significant Accounting Policies and Basis of Presentation - Narrative (Detail)	3 Months Ended
	Mar. 31, 2022 USD ($) Segment	Dec. 31, 2021 USD ($)
Accounting Policies [Line Items]
Number of operating segments | Segment	1
Off-balance sheet concentration of credit risk	$ 0
Accounts receivable, net	24,739,000	$ 29,438,000
Almirall
Accounting Policies [Line Items]
Accounts receivable, net	600,000
Tetraphase License Agreement
Accounting Policies [Line Items]
Accounts receivable, net	600,000
NUZYRA
Accounting Policies [Line Items]
Accounts receivable, net	19,900,000
BARDA Contract | Government Contract Service Revenue
Accounting Policies [Line Items]
Accounts receivable, net	700,000
BARDA Contract | Government Contract Grant Revenue
Accounting Policies [Line Items]
Accounts receivable, net	$ 2,500,000