144 0001886431 XXXXXXXX LIVE 0001178670 ALNYLAM PHARMACEUTICALS, INC. 001-36407 675 WEST KENDALL STREET HENRI A. TERMEER SQUARE CAMBRIDGE MA 02142 (617) 551-8200 Fitzgerald Kevin Joseph Officer Common UBS Financial Services, Inc.

11 Madison Ave 4th Floor New York NY 10010

658 212988.02 132623144 03/05/2026 Nasdaq Common 03/03/2026 RSU Issuer N 658 03/03/2026 NA N Kevin Fitzgerald

675 WEST KENDALL STREET HENRI A. TERMEER SQUARE CAMBRIDGE MA 02142

Common 01/13/2026 2290 848062.57 Kevin Fitzgerald

675 WEST KENDALL STREET HENRI A. TERMEER SQUARE CAMBRIDGE MA 02142

Common 02/17/2026 2041 677531.58 Kevin Fitzgerald

675 WEST KENDALL STREET HENRI A. TERMEER SQUARE CAMBRIDGE MA 02142

Common 03/03/2026 1652 528187.85 03/05/2026 08/14/2025 /s/ UBS Financial Services Inc, as attorney-in-fact for Kevin Fitzgerald