CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) shares in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Revenues	$ 33,294,000	$ 21,899,000
Costs and expenses:
Cost of goods sold	3,347,000
Research and development	129,127,000	96,857,000
Selling, general and administrative	89,608,000	72,447,000
Total costs and expenses	222,082,000	169,304,000
Loss from operations	(188,788,000)	(147,405,000)
Other income (expense):
Interest income	7,525,000	5,794,000
Other income	43,000	335,000
Total other income	7,568,000	6,129,000
Loss before income taxes	(181,220,000)	(141,276,000)
(Provision) benefit for income taxes	(695,000)	62,000
Net loss	$ (181,915,000)	$ (141,214,000)
Net loss per common share - basic and diluted	$ (1.73)	$ (1.41)
Weighted-average common shares used to compute basic and diluted net loss per common share	105,400	99,979
Comprehensive loss:
Net loss	$ (181,915,000)	$ (141,214,000)
Unrealized gain (loss) on marketable securities, net of tax	360,000	(420,000)
Comprehensive loss	(181,555,000)	(141,634,000)
Product Revenues, Net
Revenues:
Revenues	26,291,000	0
Net Revenues from Collaborators
Revenues:
Revenues	$ 7,003,000	$ 21,899,000