CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands		3 Months Ended		9 Months Ended
		Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Revenues		$ 2,069	$ 17,096	$ 53,875	$ 51,988
Costs and expenses:
Cost of goods sold		137		137
Research and development	[1]	139,945	95,252	374,384	272,863
Selling, general and administrative	[1]	116,545	47,644	273,671	131,910
Total costs and expenses		256,627	142,896	648,192	404,773
Loss from operations		(254,558)	(125,800)	(594,317)	(352,785)
Other income (expense):
Interest income		6,796	3,296	18,691	8,001
Other income (expense)		2,925	(433)	5,468	(3,863)
Gain on litigation settlement				20,564
Total other income		9,721	2,863	44,723	4,138
Loss before income taxes		(244,837)	(122,937)	(549,594)	(348,647)
Provision for income taxes		(445)		(462)
Net loss		$ (245,282)	$ (122,937)	$ (550,056)	$ (348,647)
Net loss per common share - basic and diluted		$ (2.43)	$ (1.34)	$ (5.48)	$ (3.93)
Weighted-average common shares used to compute basic and diluted net loss per common share		100,783	91,828	100,430	88,672
Comprehensive loss:
Net loss		$ (245,282)	$ (122,937)	$ (550,056)	$ (348,647)
Unrealized gain (loss) on marketable securities, net of tax		415	218	1,041	(2,194)
Reclassification adjustment for realized loss on marketable securities included in net loss					1,894
Comprehensive loss		(244,867)	(122,719)	(549,015)	(348,947)
Product Revenues, Net
Revenues:
Revenues		460		460
Net Revenues from Collaborators
Revenues:
Revenues		$ 1,609	$ 17,096	$ 53,415	$ 51,988

[1] Stock-based compensation expenses included in operating costs and expenses are as follows: Research and development $45,784 $15,090 $67,537 $37,035 Selling, general and administrative 42,170 10,865 62,242 28,667