X0306 4 2014-05-21 0 0001178670 ALNYLAM PHARMACEUTICALS, INC. ALNY 0001219015 CLARKE JOHN K C/O CARDINAL HEALTH PARTNERS 230 NASSAU STREET PRINCETON NJ 08542 1 0 0 0 Common Stock 2014-05-21 4 M 0 10000 7.08 A 10000 D Common Stock 2014-05-21 4 M 0 10000 14.74 A 20000 D Common Stock 2014-05-21 4 M 0 15000 15.91 A 35000 D Common Stock 2014-05-21 4 S 0 22792 52.954 D 12208 D Common Stock 2014-05-21 4 S 0 2500 54.2142 D 9708 D Common Stock 2014-05-21 4 S 0 6908 55.4684 D 2800 D Common Stock 2014-05-21 4 S 0 2800 56.1929 D 0 D Common Stock 8891 I By Managed Account Stock Option (Right to Buy) 7.08 2014-05-21 4 M 0 10000 0 D 2006-06-08 2015-06-08 Common Stock 10000 0 D Stock Option (Right to Buy) 14.74 2014-05-21 4 M 0 10000 0 D 2007-06-01 2016-06-01 Common Stock 10000 0 D Stock Option (Right to Buy) 15.91 2014-05-21 4 M 0 15000 0 D 2008-06-01 2017-06-01 Common Stock 15000 0 D The sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 19, 2014. Sale prices ranged from from $52.50 to $53.48. Sale prices ranged from from $53.87 to $54.50. Sale prices ranged from from $54.94 to $55.92. Sale prices ranged from from $55.94 to $56.62. These shares are owned by CHP II, L.P. The reporting person is the Managing General Partner of CHP II Management LLC, the General Partner of CHP II L.P. The reporting person may be deemed to beneficially own the shares held by CHP II, L.P. although he disclaims beneficial ownership except to the extent of his proportionate pecuniary interest therein. /s/ Michael P. Mason, Attorney-in-Fact for John K. Clarke 2014-05-23