X0303 4 2009-06-16 0 0001178670 ALNYLAM PHARMACEUTICALS, INC. ALNY 0001180432 MARAGANORE JOHN 300 THIRD ST CAMBRIDGE MA 02139 1 1 0 0 CEO Common Stock 2009-06-16 4 M 0 39600 0.475 A 39600 D Common Stock 2009-06-16 4 S 0 39600 21.4325 D 0 D Common Stock 2009-06-16 4 M 0 400 0.475 A 400 D Common Stock 2009-06-16 4 S 0 400 22.1575 D 0 D Common Stock 2009-06-17 4 M 0 40000 0.475 A 40000 D Common Stock 2009-06-17 4 S 0 40000 21.396 D 0 D Common Stock 2009-06-18 4 M 0 11800 0.475 A 11800 D Common Stock 2009-06-18 4 S 0 11800 21.3662 D 0 D Common Stock 2009-06-18 4 M 0 28200 0.475 A 28200 D Common Stock 2009-06-18 4 S 0 28200 21.3662 D 0 D Common Stock 1020 I by Managed Account Non Qualified Stock Option 0.475 2009-06-16 4 M 0 39600 0 D 2003-12-09 2013-02-26 Common Stock 39600 52200 D Non Qualified Stock Option 0.475 2009-06-16 4 M 0 400 0 D 2003-12-09 2013-02-26 Common Stock 400 51800 D Non Qualified Stock Option 0.475 2009-06-17 4 M 0 40000 0 D 2003-12-09 2013-02-26 Common Stock 40000 11800 D Non Qualified Stock Option 0.475 2009-06-18 4 M 0 11800 0 D 2003-12-09 2013-02-26 Common Stock 11800 0 D Incentive Stock Option 0.475 2009-06-18 4 M 0 28200 0 D 2003-12-09 2013-02-26 Common Stock 28200 64102 D The exercises reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 10, 2009. The sales reported on this Form 4 were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 10, 2009. Sales prices ranged from $21.06 to $22.05. Sales prices ranged from $22.09 to $22.27. Sales prices ranged from $21.12 to 21.52. Sales prices ranged from $21.11 to $21.68. The reporting person owns 1,020 shares of ALNY common stock under the ALNY 401(k) Plan as a result of the ALNY 401(k) matching contribution program. /s/ Patricia L Allen, Attorney-in-Fact for John M Maraganore 2009-06-18