CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024
Cash flows from operating activities:
Net loss	$ (123,756)	$ (82,824)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation and amortization	28,349	28,520
Non-cash interest expense on liability related to the sale of future royalties	71,434	61,103
Stock-based compensation expense	168,392	134,635
Realized and unrealized loss on marketable equity securities	2,306	1,289
Change in fair value of development derivative liability	74,150	64,228
Deferred income taxes	19,374	794
Other	(37,864)	(18,292)
Changes in operating assets and liabilities:
Accounts receivable, net	(144,347)	10,050
Inventory	17,359	6,816
Prepaid expenses and other assets	(25,992)	(13,775)
Accounts payable, accrued expenses and other liabilities	26,411	69,605
Deferred revenue	(40,400)	(219,506)
Net cash provided by operating activities	35,416	42,643
Cash flows from investing activities:
Purchases of property, plant and equipment	(23,263)	(20,991)
Purchases of marketable securities	(861,199)	(717,826)
Sales and maturities of marketable securities	856,850	705,137
Proceeds from maturity of restricted investments	58,075	57,875
Purchases of restricted investments	(58,075)	(57,875)
Net cash used in investing activities	(27,612)	(33,680)
Cash flows from financing activities:
Proceeds from exercise of stock options and other types of equity, net	130,587	158,637
(Repayment of) proceeds from development derivative, net	(32,746)	1,770
Net cash provided by financing activities	97,841	160,407
Effect of exchange rate changes on cash, cash equivalents and restricted cash	41,564	(13,061)
Net increase in cash, cash equivalents and restricted cash	147,209	156,309
Cash, cash equivalents and restricted cash, beginning of period	968,652	814,884
Cash, cash equivalents and restricted cash, end of period	1,115,861	971,193
Supplemental disclosure of cash flows:
Cash paid for interest	81,497	39,101
Cash paid for taxes	1,098	3,561
Operating lease right-of-use assets obtained in exchange for new operating lease liabilities	8,537	7,793
Supplemental disclosure of noncash investing activities:
Capital expenditures included in accounts payable and accrued expenses	$ 4,081	$ 1,063