CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2025	Dec. 31, 2024
Current assets:
Cash and cash equivalents	$ 1,113,685	$ 966,428
Marketable debt securities	1,743,900	1,719,920
Marketable equity securities	0	8,156
Accounts receivable, net	567,112	405,308
Inventory	71,688	78,509
Prepaid expenses and other current assets	147,314	116,964
Total current assets	3,643,699	3,295,285
Property, plant and equipment, net	499,791	502,784
Operating lease right-of-use assets	192,401	191,148
Deferred tax assets	104,363	116,863
Restricted investments	68,593	68,593
Other assets	57,172	65,310
Total assets	4,566,019	4,239,983
Current liabilities:
Accounts payable	102,393	88,415
Accrued expenses	918,966	793,692
Operating lease liabilities	46,097	41,886
Deferred revenue	15,080	55,481
Liability related to the sale of future royalties	97,523	113,018
Development derivative liability	120,788	93,780
Total current liabilities	1,300,847	1,186,272
Operating lease liabilities, net of current portion	224,445	229,541
Convertible debt	1,026,522	1,024,621
Liability related to the sale of future royalties, net of current portion	1,345,147	1,334,353
Development derivative liability, net of current portion	407,535	393,139
Other liabilities	10,932	4,969
Total liabilities	4,315,428	4,172,895
Commitments and contingencies (Note 12)
Stockholders' equity:
Preferred stock, $0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of June 30, 2025 and December 31, 2024	0	0
Common stock, $0.01 par value per share, 250,000 shares authorized; 130,977 shares issued and outstanding as of June 30, 2025; 129,294 shares issued and outstanding as of December 31, 2024	1,310	1,293
Additional paid-in capital	7,690,737	7,388,061
Accumulated other comprehensive loss	(29,952)	(34,518)
Accumulated deficit	(7,411,504)	(7,287,748)
Total stockholders' equity	250,591	67,088
Total liabilities and stockholders' equity	$ 4,566,019	$ 4,239,983