CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Revenues:
Total revenues	$ 1,828,292	$ 1,037,418	$ 844,287
Operating costs and expenses:
Cost of goods sold	268,216	140,174	115,005
Cost of collaborations and royalties	42,190	28,643	25,139
Research and development	1,004,415	883,015	792,156
Selling, general and administrative	795,646	770,658	620,639
Total operating costs and expenses	2,110,467	1,822,490	1,552,939
Loss from operations	(282,175)	(785,072)	(708,652)
Other (expense) income:
Interest expense	(121,221)	(155,968)	(143,021)
Interest income	95,561	24,808	1,579
Other expense, net	(125,682)	(134,175)	(2,050)
Loss on the extinguishment of debt	0	(76,586)	0
Total other expense, net	(151,342)	(341,921)	(143,492)
Loss before income taxes	(433,517)	(1,126,993)	(852,144)
Provision for income taxes	(6,725)	(4,163)	(680)
Net loss	$ (440,242)	$ (1,131,156)	$ (852,824)
Net loss per common share, basic (in dollars per share)	$ (3.52)	$ (9.30)	$ (7.20)
Net loss per common share, diluted (in dollars per share)	$ (3.52)	$ (9.30)	$ (7.20)
Weighted average common shares, basic (in shares)	124,906,000	121,689,000	118,451,000
Weighted average common shares, diluted (in shares)	124,906,000	121,689,000	118,451,000
Statements of Comprehensive Loss
Net income (loss)	$ (440,242)	$ (1,131,156)	$ (852,824)
Other comprehensive income (loss):
Unrealized gain (loss) on marketable securities	11,018	(7,840)	(1,978)
Foreign currency translation gain (loss)	11,922	(5,274)	11,398
Defined benefit pension plans, net of tax	(1,661)	1,719	943
Total other comprehensive income (loss)	21,279	(11,395)	10,363
Comprehensive loss	(418,963)	(1,142,551)	(842,461)
Net product revenues
Revenues:
Total revenues	1,241,474	894,329	662,138
Net revenues from collaborations
Revenues:
Total revenues	546,185	134,912	180,953
Royalty revenue
Revenues:
Total revenues	$ 40,633	$ 8,177	$ 1,196