NET PRODUCT REVENUES - Summary of Net Product Revenues (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Disaggregation of Revenue [Line Items]
Total revenues	$ 1,828,292	$ 1,037,418	$ 844,287
Net product revenues
Disaggregation of Revenue [Line Items]
Total revenues	1,241,474	894,329	662,138
ONPATTRO
Disaggregation of Revenue [Line Items]
Total revenues	354,546	557,608	474,737
AMVUTTRA
Disaggregation of Revenue [Line Items]
Total revenues	557,838	93,795	0
GIVLAARI
Disaggregation of Revenue [Line Items]
Total revenues	219,251	173,144	127,815
OXLUMO
Disaggregation of Revenue [Line Items]
Total revenues	109,839	69,782	59,586
United States | ONPATTRO
Disaggregation of Revenue [Line Items]
Total revenues	97,739	246,748	213,210
United States | AMVUTTRA
Disaggregation of Revenue [Line Items]
Total revenues	411,169	82,521	0
United States | GIVLAARI
Disaggregation of Revenue [Line Items]
Total revenues	141,954	115,659	92,747
United States | OXLUMO
Disaggregation of Revenue [Line Items]
Total revenues	38,159	27,698	18,876
Europe | ONPATTRO
Disaggregation of Revenue [Line Items]
Total revenues	210,916	224,063	190,435
Europe | AMVUTTRA
Disaggregation of Revenue [Line Items]
Total revenues	70,898	4,214	0
Europe | GIVLAARI
Disaggregation of Revenue [Line Items]
Total revenues	57,498	48,670	30,895
Europe | OXLUMO
Disaggregation of Revenue [Line Items]
Total revenues	60,025	37,915	38,949
Rest of World | ONPATTRO
Disaggregation of Revenue [Line Items]
Total revenues	45,891	86,797	71,092
Rest of World | AMVUTTRA
Disaggregation of Revenue [Line Items]
Total revenues	75,771	7,060	0
Rest of World | GIVLAARI
Disaggregation of Revenue [Line Items]
Total revenues	19,799	8,815	4,173
Rest of World | OXLUMO
Disaggregation of Revenue [Line Items]
Total revenues	$ 11,655	$ 4,169	$ 1,761