OTHER BALANCE SHEET DETAILS (Tables)

12 Months Ended

Dec. 31, 2023

Balance Sheet Related Disclosures [Abstract]

The components of inventory are summarized as follows:


	As of December 31,
(In thousands)	2023		2022
Raw materials	$	23,346	$	22,315
Work in process	76,963		113,783
Finished goods	25,123		25,606
Total inventory	$	125,432	$	161,704

Property, Plant and Equipment, Net

Property, plant and equipment, net consist of the following:


	As of December 31,
(In thousands)	2023		2022
Buildings	$	271,651	$	269,322
Leasehold improvements	235,411		230,848
Laboratory equipment	107,147		82,586
Manufacturing equipment	47,976		45,311
Computer equipment and software	35,616		33,370
Construction in progress	30,099		14,595
Furniture and fixtures	12,153		11,832
Land	9,080		9,080
	749,133		696,944
Less: accumulated depreciation	(223,076)		(173,450)
Total	$	526,057	$	523,494

Accrued Expenses

Accrued expenses consist of the following:


	As of December 31,
(In thousands)	2023		2022
Product rebates and discounts	$	345,941	$	208,998
Compensation and related	122,170		130,690
Pre-clinical, clinical trial and manufacturing	111,503		94,702
Licensing and collaboration agreements	58,282		31,680
Consulting and professional services	21,155		19,848
Other	53,962		59,542
Total	$	713,013	$	545,460

Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash

The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within our consolidated balance sheets that sum to the total of these amounts shown in the consolidated statements of cash flows:


	As of December 31,
(In thousands)	2023		2022		2021
Cash and cash equivalents	$	812,688	$	866,394	$	819,975
Total restricted cash included in other assets	2,196		2,162		2,178
Total cash, cash equivalents, and restricted cash shown in the consolidated statements of cash flows	$	814,884	$	868,556	$	822,153

Summary of Changes in Accumulated Other Comprehensive Income (Loss)

The following table summarizes the changes in accumulated other comprehensive (loss) income, by component:


(In thousands)	Loss on Investment in Joint Venture		Defined Benefit Pension Plans, Net of Tax		Unrealized Gains (Losses) from Debt Securities		Foreign Currency Translation Adjustment		Total Accumulated Other Comprehensive (Loss) Income
Balance as of December 31, 2021	$	(32,792)	$	(2,811)	$	(1,630)	$	3,974	$	(33,259)
Other comprehensive loss before reclassifications	—		—		11		(5,274)		(5,263)
Amounts reclassified from other comprehensive loss	—		1,719		(7,851)		—		(6,132)
Net other comprehensive loss	—		1,719		(7,840)		(5,274)		(11,395)
Balance as of December 31, 2022	(32,792)		(1,092)		(9,470)		(1,300)		(44,654)
Other comprehensive income before reclassifications	—		—		(6)		11,922		11,916
Amounts reclassified from other comprehensive income	—		(1,661)		11,024		—		9,363
Net other comprehensive income	—		(1,661)		11,018		11,922		21,279
Balance as of December 31, 2023	$	(32,792)	$	(2,753)	$	1,548	$	10,622	$	(23,375)