NET PRODUCT REVENUES

12 Months Ended

Dec. 31, 2023

Revenue from Contract with Customer [Abstract]

NET PRODUCT REVENUES

NET PRODUCT REVENUES

Net product revenues, classified based on the geographic region in which the product is sold, consist of the following: 

	Year Ended December 31,
(In thousands)	2023		2022		2021
ONPATTRO
United States	$	97,739	$	246,748	$	213,210
Europe	210,916		224,063		190,435
Rest of World	45,891		86,797		71,092
Total	354,546		557,608		474,737
AMVUTTRA
United States	411,169		82,521		—
Europe	70,898		4,214		—
Rest of World	75,771		7,060		—
Total	557,838		93,795		—
GIVLAARI
United States	141,954		115,659		92,747
Europe	57,498		48,670		30,895
Rest of World	19,799		8,815		4,173
Total	219,251		173,144		127,815
OXLUMO
United States	38,159		27,698		18,876
Europe	60,025		37,915		38,949
Rest of World	11,655		4,169		1,761
Total	109,839		69,782		59,586
Total net product revenues	$	1,241,474	$	894,329	$	662,138

As of December 31, 2023 and 2022, net product revenue-related receivables of $210.1 million and $203.8 million, respectively, were included in “Accounts receivable, net.”

The following table summarizes balances and activity in each product revenue allowance and reserve category:

	As of December 31, 2023
(In thousands)	Chargebacks and Rebates		Trade Discounts and Allowances		Returns Reserve and Other Incentives		Total
Beginning balance	$	191,772	$	2,450	$	14,776	$	208,998
Provision related to current period sales	367,005		18,500		19,487		404,992
Credit or payments made during the period for current year sales	(147,749)		(16,137)		(15,134)		(179,020)
Credit or payments made during the period for prior year sales	(85,356)		(1,696)		(1,977)		(89,029)
Total	$	325,672	$	3,117	$	17,152	$	345,941

	As of December 31, 2022
(In thousands)	Chargebacks and Rebates		Trade Discounts and Allowances		Returns Reserve and Other Incentives		Total
Beginning balance	$	120,682	$	522	$	10,112	$	131,316
Provision related to current period sales	245,236		13,085		15,249		273,570
Credit or payments made during the period for current year sales	(108,185)		(10,310)		(9,850)		(128,345)
Credit or payments made during the period for prior period sales	(65,961)		(847)		(735)		(67,543)
Total	$	191,772	$	2,450	$	14,776	$	208,998