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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Cash flows from operating activities:    
Net loss $ (182,221) $ (181,915)
Non-cash adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 7,613 3,838
Amortization and interest accretion related to operating leases 9,393 10,255
Stock-based compensation 34,578 32,032
Unrealized gain on marketable equity securities (24,111) 0
Other 660 (1,075)
Changes in operating assets and liabilities:    
Accounts receivable, net (32,882) (15,041)
Proceeds from landlord lease incentive for tenant improvements 0 12,386
Inventory (11,952) (7,134)
Prepaid expenses and other assets (19,958) (8,988)
Accounts payable, accrued expenses and other liabilities (14,215) (24,332)
Deferred revenue (4,030) (834)
Operating lease liability (9,036) (7,702)
Net cash used in operating activities (246,161) (188,510)
Cash flows from investing activities:    
Purchases of property, plant and equipment (19,617) (44,049)
Purchases of marketable debt securities (396,409) (256,996)
Sales and maturities of marketable securities 539,614 403,697
Purchases of restricted investments (9,900) 0
Net cash provided by investing activities 113,688 102,652
Cash flows from financing activities:    
Proceeds from exercise of stock options and other types of equity, net 53,869 9,031
Offering proceeds, net of costs 0 381,900
Net cash provided by financing activities 53,869 390,931
Effect of exchange rate changes on cash, cash equivalents and restricted cash (631) 0
Net (decrease) increase in cash, cash equivalents and restricted cash (79,235) 305,073
Cash, cash equivalents and restricted cash, beginning of period 549,628 422,631
Cash, cash equivalents and restricted cash, end of period 470,393 727,704
Supplemental disclosure of noncash investing and financing activities:    
Capital expenditures included in accounts payable and accrued expenses 6,619 13,033
Lease liabilities arising from obtaining right-of-use assets $ 2,939 $ 0