CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenues:
Total revenues	$ 99,476	$ 33,294
Operating costs and expenses:
Cost of goods sold	13,302	3,347
Research and development	169,571	129,127
Selling, general and administrative	126,761	89,608
Total operating costs and expenses	309,634	222,082
Loss from operations	(210,158)	(188,788)
Other income:
Interest income	5,480	7,525
Other income	23,032	43
Total other income	28,512	7,568
Loss before income taxes	(181,646)	(181,220)
Provision for income taxes	(575)	(695)
Net loss	$ (182,221)	$ (181,915)
Net loss per common share - basic and diluted (in dollars per share)	$ (1.62)	$ (1.73)
Weighted-average common shares used to compute basic and diluted net loss per common share (in shares)	112,748	105,400
Statements of Comprehensive Loss
Net loss	$ (182,221)	$ (181,915)
Unrealized gain on marketable debt securities	4,045	360
Foreign currency translation	340	0
Defined benefit pension plans, net of tax	74	0
Comprehensive loss	(177,762)	(181,555)
Net revenues from collaborations
Revenues:
Total revenues	27,538	7,003
Net product revenues
Revenues:
Total revenues	$ 71,938	$ 26,291