Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

The Board of Directors
Saia, Inc.:

We consent to the incorporation by reference in the registration statements (Nos. 333-155805, 333-104929, 333-104694 and 333-100649) on Form S-8 and (No. 333-164321) on Form S-3 of Saia, Inc. of our reports dated February 25, 2010, with respect to the consolidated balance sheets of Saia, Inc. and subsidiary as of December 31, 2009 and 2008, and the related consolidated statements of operations, shareholders’ equity, and cash flows for each of the years in the three-year period ended December 31, 2009, and the effectiveness of internal control over financial reporting as of December 31, 2009, which reports appear in the December 31, 2009 annual report on Form 10-K of Saia, Inc. Our report with respect to the consolidated financial statements refers to the adoption by the Company of Financial Accounting Standards Board Interpretation No. 48, Accounting for Uncertainty in Income Taxes, included in ASC subtopic 740-10 Income Taxes — Overall, in 2007.

/s/ KPMG LLP

Atlanta, Georgia
February 25, 2010