X0508 4 2023-12-05 0001177648 ENANTA PHARMACEUTICALS INC ENTA 0001607643 Gardiner Nathaniel S. C/O ENANTA PHARMACEUTICALS, INC. 500 ARSENAL STREET WATERTOWN MA 02472 0 1 0 0 Sr. VP & General Counsel 0 Common Stock 2023-12-05 4 S 0 2412 9.63 D 68154 D Common Stock 35926 I By grantor retained annuity trust Represents shares sold by the reporting person to cover withholding taxes due as a result of settlement of a portion of the restricted stock unit award granted on November 23, 2022, as required pursuant to the terms of the award. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the reporting person. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $9.47 to $9.63, inclusive. The reporting person undertakes to provide to Enanta Pharmaceuticals, Inc., any security holder of Enanta Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth set forth in this footnote of this Form 4. These shares are held by grantor retained annuity trusts created by the reporting person for the benefit of himself and his two adult children. /s/ Nathaniel S. Gardiner 2023-12-06