X0508 4 2023-12-01 0001177648 ENANTA PHARMACEUTICALS INC ENTA 0001607643 Gardiner Nathaniel S. C/O ENANTA PHARMACEUTICALS, INC. 500 ARSENAL STREET WATERTOWN MA 02472 0 1 0 0 Sr. VP & General Counsel 0 Common Stock 2023-12-01 4 F 0 1595 9.49 D 70566 D Common Stock 35926 I By grantor retained annuity trust Represents the number of shares of ENTA common stock forfeited by the reporting person to cover withholding taxes due as a result of settlement of a portion of the restricted stock unit awards granted on November 20, 2020 and November 19, 2021. These shares are held by grantor retained annuity trusts created by the reporting person for the benefit of himself and his two adult children. Since April 2023, the reporting person's holdings in these trusts have increased by a net 7,819 shares of common stock. /s/ Nathaniel S. Gardiner 2023-12-05