X0306 4 2018-09-28 0 0000879169 INCYTE CORP INCY 0001175940 BROOKE PAUL A 1801 AUGUSTINE CUT-OFF WILMINGTON DE 19803 1 0 0 0 Common Stock 2018-09-28 4 A 0 343 69.08 A 198556 D Common Stock 40000 I By the Paul Brooke Family Trusts Restricted shares issued to the Reporting Person under the Issuer's Amended and Restated 2010 Stock Incentive Plan in lieu of quarterly director retainer fees pursuant to an election by the Reporting Person intended to comply with Rule 10b5-1. Restricted shares are fully vested. Represents previously reported shares contributed to the Paul Brooke Family Trusts. /s/ Michael J. Purvis, Attorney-In-Fact 2018-10-02