CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($)	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Total
Balance at Dec. 31, 2018	$ 31,774	$ 186,138,466	$ 288,175	$ (169,523,815)	$ 16,934,600
Balance (in shares) at Dec. 31, 2018	31,774,139
Stock-based compensation - employees, consultants and directors	$ 0	1,666,024	0	0	1,666,024
Issuance of common stock - offerings, net of fees incurred	$ 192	673,461	0	0	673,653
Issuance of common stock - offerings, net of fees incurred (in shares)	191,244
Issuance of restricted stock options	$ 84	663,284	0	0	663,368
Issuance of restricted stock options (in shares)	84,249
Proceeds from exercise of warrants	$ 361	1,768,130	0	0	1,768,491
Proceeds from exercise of warrants (in shares)	360,358
Cashless exercise of warrants	$ 9	(9)	0	0	0
Cashless exercise of warrants (in shares)	9,029
Proceeds from exercise of stock options	$ 174	739,573	0	0	739,747
Proceeds from exercise of stock options (in shares)	173,734
Cashless exercise of stock options	$ 22	(22)	0	0	0
Cashless exercise of stock options (in shares)	23,354
Other comprehensive income, foreign translation adjustment	$ 0	0	237,803	0	237,803
Net loss	0	0	0	(19,265,644)	(19,265,644)
Balance at Dec. 31, 2019	$ 32,616	191,648,907	525,978	(188,789,459)	3,418,042
Balance (in shares) at Dec. 31, 2019	32,616,107
Stock-based compensation - employees, consultants and directors	$ 0	3,513,671	0	0	3,513,671
Issuance of common stock - offerings, net of fees incurred	$ 10,162	80,203,846	0	0	80,214,008
Issuance of common stock - offerings, net of fees incurred (in shares)	10,163,256
Issuance of restricted stock options	$ 88	657,692	0	0	657,780
Issuance of restricted stock options (in shares)	87,728
Proceeds from exercise of warrants	$ 342	1,508,980	0	0	1,509,322
Proceeds from exercise of warrants (in shares)	341,507
Cashless exercise of stock options	$ 14	(14)	0	0	0
Cashless exercise of stock options (in shares)	13,401
Other comprehensive income, foreign translation adjustment	$ 0	0	(2,260,056)	0	(2,260,056)
Net loss	0	0	0	(7,837,188)	(7,837,188)
Balance at Dec. 31, 2020	$ 43,222	277,533,082	(1,734,078)	(196,626,647)	79,215,579
Balance (in shares) at Dec. 31, 2020	43,221,999
Stock-based compensation - employees, consultants and directors	$ 0	4,020,819	0	0	4,020,819
Issuance of common stock - offerings, net of fees incurred	0	(90,000)	0	0	$ (90,000)
Issuance of common stock - offerings, net of fees incurred (in shares)					4,301,869
Issuance of restricted stock options	$ 107	928,310	0	0	$ 928,417
Issuance of restricted stock options (in shares)	106,662
Proceeds from exercise of stock options	$ 139	805,060	0	0	805,199
Proceeds from exercise of stock options (in shares)	139,102
Cashless exercise of stock options	$ 10	(2,842)	0	0	(2,832)
Cashless exercise of stock options (in shares)	10,724
Other comprehensive income, foreign translation adjustment	$ 0	0	2,259,663	0	2,259,663
Net loss	0	0	0	(24,558,648)	(24,558,648)
Balance at Dec. 31, 2021	$ 43,478	$ 283,194,429	$ 525,585	$ (221,185,295)	$ 62,578,197
Balance (in shares) at Dec. 31, 2021	43,478,487