X0202 4 2006-03-01 1 0001174891 UPSTREAM BIOSCIENCES INC. UPBS 0001242939 MICHEL JOHNNY 0 0 1 0 Common shares 2006-03-01 4 I 0 37500000 0 D 0 D Mr. Michel initially owned 1,250,000 common shares of the Issuer. The Issuer completed a 20 for 1 forward stock split on March 8, 2005 and a 1.5 for 1 forward stock split on December 20, 2005. As a result of the two stock splits, Mr. Michel held 37,500,000 common shares. On March 1, 2006, Mr. Michel tendered 37,500,000 common shares for cancellation without consideration. /s/ Johnny Michel 2006-03-10