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N/A 413197104 3187.00000000 NS USD 110493.29000000 0.142584426953 Long EC CORP US N 1 N N N Ocular Therapeutix, Inc. 529900ABAWFXOHSIHG03 67576A100 8741.00000000 NS USD 86448.49000000 0.111556171489 Long EC CORP US N 1 N N N Avadel Pharmaceuticals plc 549300E27PTSG2RHC762 N/A 5396.00000000 NS USD 59679.76000000 0.077012860964 Long EC CORP IE N 1 N N N Erasca, Inc. N/A 29479A108 15833.00000000 NS USD 45282.38000000 0.058433975523 Long EC CORP US N 1 N N N Aclaris Therapeutics, Inc. 5493000B2LQ9QTW1DF52 00461U105 4000.00000000 NS USD 16280.00000000 0.021008284492 Long EC CORP US N 1 N N N Repurchase Agreement N/A 000000000 3632803.70000000 PA USD 3632803.70000000 4.687897643361 Long RA CORP US N 2 Repurchase N 4.15000000 2024-12-02 3632803.70000000 USD 3705459.77390000 USD UST N N N Moderna, Inc. 549300EI6OKH5K5Q2G38 60770K107 21550.00000000 NS USD 927943.00000000 1.197450278657 Long EC CORP US N 1 N N N Dynavax Technologies Corp. 549300T5URIXWDILX594 268158201 7343.00000000 NS USD 94430.98000000 0.121857057292 Long EC CORP US N 1 N N N Alkermes plc N/A N/A 9233.00000000 NS USD 267941.66000000 0.345761340331 Long EC CORP IE N 1 N N N N/A N/A N/A 5801.00000000 NC USD -1446794.74000000 -1.86699480956 N/A DE US N 2 UBS AG 254900R882POXXVAK772 NASDAQ Biotechnology Index NBI Y 2026-11-06 0.00000000 USD 0.00000000 USD 26944542.81000000 USD -1446794.74000000 N N N Veracyte, Inc. 529900ESWZRHXOW27Z37 92337F107 4305.00000000 NS USD 184899.75000000 0.238601139467 Long EC CORP US N 1 N N N Anavex Life Sciences Corp. 549300K1I5L8COCQ8W36 032797300 4754.00000000 NS USD 44972.84000000 0.058034534222 Long EC CORP US N 1 N N Terns Pharmaceuticals, Inc. 254900S1ZDQMF4MYP709 880881107 3944.00000000 NS USD 24610.56000000 0.031758332063 Long EC CORP US N 1 N N N Verve Therapeutics, Inc. 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