X0306 4 2013-08-12 0 0001172480 SANTARUS INC SNTS 0001279192 CRAWFORD DEBRA P SANTARUS, INC. 3611 VALLEY CENTRE DRIVE #400 SAN DIEGO CA 92130 0 1 0 0 Sr. VP, CFO, Sec'y, Treas Common Stock 2013-08-12 4 M 0 19000 1.18 A 185326 D Common Stock 2013-08-12 4 S 0 19000 26.3968 D 166326 D Stock Options (right to buy) 1.18 2013-08-12 4 M 0 19000 D 2009-03-16 2019-03-16 Common Stock 19000 78000 D This exercise and this sale were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on 11/12/2012. The price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.21 to $26.78. The reporting person undertakes to provide to Santarus, Inc., any security holder of Santarus, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within this range. 1/48 vest monthly from 03/16/2009. Not applicable to this transaction. /s/ Teri L. Chuppe Attorney-in-fact 2013-08-13