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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 Q8RipJoNATe2oZ+vK9QxCg==

<SEC-DOCUMENT>0001144204-10-019297.txt : 20100409
<SEC-HEADER>0001144204-10-019297.hdr.sgml : 20100409
<ACCEPTANCE-DATETIME>20100409120329
ACCESSION NUMBER:		0001144204-10-019297
CONFORMED SUBMISSION TYPE:	D/A
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100409
DATE AS OF CHANGE:		20100409
EFFECTIVENESS DATE:		20100409

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FIRST RELIANCE BANCSHARES INC
		CENTRAL INDEX KEY:			0001172102
		STANDARD INDUSTRIAL CLASSIFICATION:	NATIONAL COMMERCIAL BANKS [6021]
		IRS NUMBER:				800030931
		STATE OF INCORPORATION:			SC
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D/A
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-70291
		FILM NUMBER:		10741578

	BUSINESS ADDRESS:	
		STREET 1:		2170 W PALMETTO ST
		CITY:			FLORENCE
		STATE:			SC
		ZIP:			29501
		BUSINESS PHONE:		8436628802

	MAIL ADDRESS:	
		STREET 1:		2170 W PALMETTO ST
		CITY:			FLORENCE
		STATE:			SC
		ZIP:			29501
</SEC-HEADER>
<DOCUMENT>
<TYPE>D/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001172102</cik>
        <entityName>FIRST RELIANCE BANCSHARES INC</entityName>
        <issuerAddress>
            <street1>2170 W. Palmetto Street</street1>
            <city>Florence</city>
            <stateOrCountry>SC</stateOrCountry>
            <zipCode>29501</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>843-656-5000</issuerPhoneNumber>
        <jurisdictionOfInc>SOUTH CAROLINA</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>F.</firstName>
                <middleName>R.</middleName>
                <lastName>Saunders, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Paul</firstName>
                <middleName>C.</middleName>
                <lastName>Saunders</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>A.</firstName>
                <middleName>Dale</middleName>
                <lastName>Porter</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Leonard</firstName>
                <middleName>A.</middleName>
                <lastName>Hoogenboom</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>M.</middleName>
                <lastName>Jebaily</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Andrew</firstName>
                <middleName>G.</middleName>
                <lastName>Kampiziones</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>C.</firstName>
                <middleName>Dale</middleName>
                <lastName>Lusk</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>A.</firstName>
                <middleName>Joe</middleName>
                <lastName>Willis</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jeffrey</firstName>
                <middleName>A.</middleName>
                <lastName>Paolucci</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2170 W. Palmetto Street</street1>
                <city>Florence</city>
                <stateOrCountry>SC</stateOrCountry>
                <zipCode>29501</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Commercial Banking</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$25,000,001 - $100,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001144204-10-019171</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-04-09</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Compass Point Research and Trading, LLC</recipientName>
                <recipientCRDNumber>126258</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1775 I Street</street1>
                    <street2>Suite 800</street2>
                    <city>Washington</city>
                    <stateOrCountry>DC</stateOrCountry>
                    <zipCode>20006</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>NC</state>
                    <state>SC</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>15000003</totalOfferingAmount>
            <totalAmountSold>3823652</totalAmountSold>
            <totalRemaining>11176351</totalRemaining>
            <clarificationOfResponse>The Company offered up to $15,000,003 of capital stock without a minimum amount necessary to close.  The Company has elected to close the offering after selling $3,823,652 of capital stock.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>75</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>120000</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>FIRST RELIANCE BANCSHARES INC</issuerName>
                <signatureName>/s/ Jeffrey A. Paolucci</signatureName>
                <nameOfSigner>Jeffrey A. Paolucci</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2010-04-09</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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