SEC Form 3
FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person*
QUAKER BIO VENTURES LP

(Last) (First) (Middle)
2929 ARCH STREET

(Street)
PHILADELPHIA PA 19104

(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
04/01/2011
3. Issuer Name and Ticker or Trading Symbol
TRANZYME INC [ TZYM ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Convertible Preferred Stock (1) (1) Common Stock 2,189,791 (1) D(2)
1. Name and Address of Reporting Person*
QUAKER BIO VENTURES LP

(Last) (First) (Middle)
2929 ARCH STREET

(Street)
PHILADELPHIA PA 19104

(City) (State) (Zip)
1. Name and Address of Reporting Person*
QUAKER BIOVENTURES CAPITAL LP

(Last) (First) (Middle)
2929 ARCH STREET

(Street)
PHILADELPHIA PA 19104

(City) (State) (Zip)
1. Name and Address of Reporting Person*
Gavin Brenda D

(Last) (First) (Middle)
2929 ARCH STREET

(Street)
PHILADELPHIA PA 19104

(City) (State) (Zip)
Explanation of Responses:
1. The shares of Series A Convertible Preferred Stock owned of record by the Reporting Person will convert automatically into the number of shares of Common Stock set forth above, without the payment of any additional consideration upon the closing of the Issuer's initial public offering, which is anticipated to occur on April 6, 2011. The Series A Convertible Preferred Stock does not have an expiration date.
2. These securities are owned of record by Quaker BioVentures, L.P. Quaker BioVentures Capital, L.P. is the managing partner of Quaker BioVentures, L.P. and has voting and dispositive power over the shares held by Quaker BioVentures, L.P. Voting and investment determinations made by Quaker BioVentures Capital, L.P. with respect to the shares held by Quaker BioVentures, L.P. are made by an investment committee comprised of the following managers of Quaker BioVentures Capital, L.P.: Brenda D. Gavin, P. Sherrill Neff and Ira M. Lubert, each of whom disclaims beneficial ownership of such securities except to the extent of his or her pecuniary interest therein.
Remarks:
Exhibit 24.1 Power of attorney
/s/ P. Sherrill Neff, member of Quaker BioVentures Capital, LLC, the general partner of Quaker BioVentures Capital, L.P. 04/01/2011
/s/ P. Sherrill Neff, member of Quaker BioVentures Capital, LLC, the general partner of Quaker BioVentures Capital, L.P., the general partner of Quaker BioVentures, L.P. 04/01/2011
/s/ Richard I. Eisenstadt for Brenda Gavin, attorney-in-fact 04/01/2011
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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