Condensed Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Total	ATM Offering	Purchase Agreement	Series A Convertible Preferred Stock	Common Stock	Common Stock ATM Offering	Common Stock Purchase Agreement	Additional Paid-In Capital	Additional Paid-In Capital ATM Offering	Additional Paid-In Capital Purchase Agreement	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Balance at Dec. 31, 2020	$ 14,484,660			$ 24	$ 5,200			$ 205,661,999			$ 5,298	$ (191,187,861)
Balance, shares at Dec. 31, 2020				23,770	5,199,997
Stock-based compensation expense	337,823							337,823
Release of restricted stock awards	1				$ 1
Release of restricted stock awards, shares					1,390
Net share settlement of restricted stock awards	(1,197)							(1,197)
Net share settlement of restricted stock award, shares					(250)
Employee stock purchase plan expense	13,115							13,115
Issuance of common stock		$ 6,855,198				$ 1,058			$ 6,854,140
Issuance of common stock, shares						1,058,045
Exercise of stock options	326							326
Exercise of stock options, shares					75
Net loss	(4,848,307)											(4,848,307)
Foreign currency translation adjustment	(1,557)										(1,557)
Balance at Mar. 31, 2021	16,840,062			$ 24	$ 6,259			212,866,206			3,741	(196,036,168)
Balance, shares at Mar. 31, 2021				23,770	6,259,257
Balance at Dec. 31, 2021	10,399,824			$ 24	$ 7,588			218,723,349			1,894	(208,333,031)
Balance, shares at Dec. 31, 2021				23,770	7,588,085
Stock-based compensation expense	251,214							251,214
Release of restricted stock awards					$ 4			(4)
Release of restricted stock awards, shares					4,148
Net share settlement of restricted stock awards	(8,129)				$ (1)			(8,128)
Net share settlement of restricted stock award, shares					(1,500)
Employee stock purchase plan expense	16,591							16,591
Issuance of common stock			$ 7,108,786				$ 834			$ 7,107,952
Issuance of common stock, shares							834,054
Conversion of Series A convertible preferred stock for common stock				$ (24)	$ 158			(134)
Conversion of Series A convertible preferred stock for common stock, shares				(23,770)	158,466
Net loss	(6,497,519)											(6,497,519)
Foreign currency translation adjustment	(2,293)										(2,293)
Balance at Mar. 31, 2022	$ 11,268,474				$ 8,583			$ 226,090,840			$ (399)	$ (214,830,550)
Balance, shares at Mar. 31, 2022					8,583,253