Basic loss per common share is computed by dividing net loss allocable to common stockholders by the weighted average number of shares of common stock or common stock equivalents outstanding. Diluted loss per common share is computed similar to basic loss per common share except that it reflects the potential dilution that could occur if dilutive securities or other obligations to issue common stock were exercised or converted into common stock.

In connection with the March 2022 Purchase Agreement (see Note 13), the Company issued and sold pre-funded warrants exercisable for an aggregate of 2,410,933 shares of common stock. Each pre-funded warrant has an exercise price of $0.001 per share and does not expire until exercised in full. As the remaining shares underlying the pre-funded warrants are issuable for nominal consideration of $0.001 per share, 2,410,933 unexercised pre-funded warrants were considered outstanding for purposes of the calculation of loss per share as of March 31, 2022.

The following common stock equivalents were excluded from the computation of diluted net loss per share for the periods presented because their effect would have been anti-dilutive:

	Three Months Ended March 31,
	2022		2021
Options to purchase common stock		537,466		453,495
Series A Preferred		—		158,545
Common stock warrants		6,539,011		58,688
Restricted stock units		22,881		8,451