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Consolidated Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Operating activities    
Net loss $ (17,145,170) $ (20,870,218)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 721,246 1,346,560
Accretion of discount on NuvoGen obligation (12,288) (12,936)
Provision for excess inventory 174,589 53,298
Amortization of QNAH Convertible Note issuance costs   6,505
Amortization of MidCap Credit Facility discount and issuance costs   101,482
Amortization of SVB Term Loan discount and issuance costs 470,281 243,541
Stock-based compensation expense 1,317,355 1,584,785
Employee stock purchase plan expense 57,669 21,186
Bad debt expense 20,315  
Non-cash operating lease expense 458,001 629,501
Accrued interest on available-for-sale securities investments (25,018) (72,503)
Stock compensation expense in connection with LP Purchase Agreement   205,538
Gain on forgiveness of PPP Loan (1,735,792)  
Loss on extinguishment of Midcap Credit Facility and QNAH Convertible Note   522,394
Loss on abandonment and disposal of assets, net 180,008 105,063
Changes in operating assets and liabilities:    
Accounts receivable (805,736) 1,575,409
Inventory (1,365,384) (256,940)
Prepaid expenses and other 619,226 284,921
Deferred offering costs   140,320
Accounts payable 453,337 (23,801)
Accrued liabilities 616,447 (409,035)
Contract liabilities (38,314) (683,716)
Operating lease liabilities (469,326) (783,731)
Net cash used in operating activities (16,508,554) (16,292,377)
Investing activities    
Purchase of property and equipment (644,381) (453,552)
Maturities of available-for-sale securities 12,600,000 31,650,000
Purchase of available-for-sale securities (18,620,363) (12,465,341)
Net cash (used in) provided by investing activities (6,664,744) 18,731,107
Financing activities    
Proceeds from issuance of SVB Term Loan   10,000,000
Payment of SVB Term Loan issuance costs   (115,193)
Proceeds from ATM Offering, net of commissions of $0.3 million 10,665,819 7,545,838
Proceeds from LP Purchase Agreement 899,980 976,545
Proceeds from PPP Loan   1,717,000
Proceeds from Series A convertible preferred stock in private placement   562,955
Payments on NuvoGen obligation (530,656) (645,949)
Proceeds from exercise of pre-funded warrants   31,768
Payments on financing leases (22,563) (41,134)
Proceeds from exercise of stock options 326  
Taxes paid for net share settlement of restricted stock awards (3,239) (14,049)
Cash in lieu of fractional shares related to reverse stock split   (560)
Proceeds from shares purchased under stock purchase plans 125,828 40,976
Payments on 2021 and 2020 Insurance Notes (743,873) (570,096)
Net cash provided by financing activities 10,391,622 9,049,478
Effect of exchange rates on cash (16,186) 19,609
Increase (decrease) in cash, cash equivalents and restricted cash (12,797,862) 11,507,817
Cash, cash equivalents and restricted cash at beginning of year 22,397,812 10,889,995
Cash and cash equivalents at end of year 9,599,950 22,397,812
Supplemental disclosure of noncash investing and financing activities    
Issuance of Series A convertible preferred stock in exchange for outstanding common stock   2,424,900
Issuance of common stock upon conversion of Series A convertible preferred stock   1,622,500
Issuance of common stock warrants in connection with SVB Term Loan   420,000
Issuance of common stock from cashless exercise of pre-funded warrants 145  
Operating lease right-of-use assets obtained in exchange for operating lease liabilities 1,302,457 447,987
Carrying value of demonstration units transferred from property and equipment to inventory 16,128 18,817
2021 and 2020 Insurance Notes issued for insurance premiums 746,360 735,195
Reclassification of contract liability to refund liability   281,722
Disposal of fully depreciated assets 635,870  
Gain on forgiveness of PPP Loan 1,735,792  
Supplemental cash flow information    
Cash paid for interest 599,922 869,857
Cash paid for taxes $ 12,665 17,514
QNAH Convertible Note    
Financing activities    
Payments for extinguishment of debt   (3,000,000)
MidCap Credit Facility    
Financing activities    
Payments for extinguishment of debt   $ (7,438,623)