Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Total	L P Purchase Agreement	ATM Offering	Private Placement	Series A Convertible Preferred Stock	Series A Convertible Preferred Stock Private Placement	Common Stock	Common Stock L P Purchase Agreement	Common Stock ATM Offering	Additional Paid-In Capital	Additional Paid-In Capital L P Purchase Agreement	Additional Paid-In Capital ATM Offering	Additional Paid-In Capital Private Placement	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Balance at Dec. 31, 2019	$ 23,969,634						$ 3,873			$ 194,288,368				$ (4,964)	$ (170,317,643)
Balance, shares at Dec. 31, 2019							3,872,682
Stock-based compensation expense	1,584,666									1,584,666
Release of restricted stock awards	119						$ 8			111
Release of restricted stock awards, shares							7,911
Net share settlement of restricted stock awards	(14,049)						$ (2)			(14,047)
Net share settlement of restricted stock award, shares							(1,764)
Stock issued under stock purchase plans	$ 62,162						$ 6			62,156
Stock issued under stock purchase plans, shares	0						6,286
Issuance of common stock			$ 7,545,838						$ 955			$ 7,544,883
Issuance of common stock, shares									955,240
Issuance of preferred stock	$ 2,424,900			$ 562,955	$ 41	$ 10				2,424,859			$ 562,945
Issuance of preferred stock, shares					41,100	10,170
Cancellation of common stock received in exchange for Series A convertible preferred stock	(2,424,900)						$ (274)			(2,424,626)
Cancellation of common stock received in exchange for Series A convertible preferred stock, shares							(274,000)
Conversion of Series A convertible preferred stock for common stock					$ (27)		$ 183			(156)
Conversion of Series A convertible preferred stock for common stock, shares					(27,500)		183,333
Shares issued, including stock compensation expense		$ 1,182,083						$ 239			$ 1,181,844
Shares issued, including stock compensation expense, shares								238,658
Exercise of pre-funded warrants	31,768						$ 212			31,556
Exercise of pre-funded warrants, shares							211,784
Issuance of common stock warrants in connection with SVB Term Loan	420,000									420,000
Cash in lieu of fractional shares related to reverse stock split	(560)									(560)
Cash in lieu of fractional shares related to reverse stock split, shares							(133)
Net loss	(20,870,218)														(20,870,218)
Unrealized gain on short-term investments	9													9
Foreign currency translation adjustment	10,253													10,253
Balance at Dec. 31, 2020	14,484,660				$ 24		$ 5,200			205,661,999				5,298	(191,187,861)
Balance, shares at Dec. 31, 2020					23,770		5,199,997
Stock-based compensation expense	1,317,351									1,317,351
Release of restricted stock awards	4						$ 4
Release of restricted stock awards, shares							4,529
Net share settlement of restricted stock awards	(3,239)									(3,239)
Net share settlement of restricted stock award, shares							(611)
Employee stock purchase plan expense	57,669									57,669
Stock issued under stock purchase plans	$ 125,828						$ 34			125,794
Stock issued under stock purchase plans, shares	0						33,963
Issuance of common stock		$ 899,980	$ 10,665,819					$ 154	$ 2,051		$ 899,826	$ 10,663,768
Issuance of common stock, shares								154,372	2,050,879
Conversion of Series A convertible preferred stock for common stock, shares							144,881
Exercise of pre-funded warrants							$ 145			(145)
Exercise of pre-funded warrants, shares							144,881
Net loss	$ (17,145,170)														(17,145,170)
Exercise of stock options	326									326
Exercise of stock options, shares							75
Foreign currency translation adjustment	(3,404)													(3,404)
Balance at Dec. 31, 2021	$ 10,399,824				$ 24		$ 7,588			$ 218,723,349				$ 1,894	$ (208,333,031)
Balance, shares at Dec. 31, 2021					23,770		7,588,085