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Condensed Consolidated Statements of Cash Flows - USD ($)
6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Operating activities    
Net loss $ (7,463,259) $ (11,168,449)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 375,334 700,276
Accretion of discount on NuvoGen obligation (6,149) (6,656)
Provision for excess inventory 5,507 1,672
Amortization of QNAH Convertible Note issuance costs   6,505
Amortization of MidCap Credit Facility discount and issuance costs   101,482
Amortization of SVB Term Loan discount and issuance costs 234,927 3,389
Stock-based compensation expense 677,194 776,793
Employee stock purchase plan expense 26,231 10,758
Non-cash operating lease expense 254,584 306,230
Accrued interest on available-for-sale securities investments (10,530) (98,092)
Stock compensation expense in connection with LP Purchase Agreement   205,538
Gain on forgiveness of PPP Loan (1,735,792)  
Loss on extinguishment of Midcap Credit Facility and QNAH Convertible Note   522,394
Loss on abandonment and disposal of assets, net 178,925 49,226
Changes in operating assets and liabilities:    
Accounts receivable (114,735) 2,152,714
Inventory (831,511) (120,575)
Prepaid expenses and other (573,569) 171,774
Deferred offering costs   140,320
Accounts payable 443,816 (659,736)
Accrued liabilities (117,926) (1,047,223)
Contract liabilities 21,241 (53,284)
Operating lease liabilities (266,464) (378,840)
Net cash used in operating activities (8,902,176) (8,383,784)
Investing activities    
Purchase of property and equipment (241,474) (322,372)
Maturities of available-for-sale securities 6,300,000 17,950,000
Purchase of available-for-sale securities (16,173,223) (4,272,298)
Net cash (used in) provided by investing activities (10,114,697) 13,355,330
Financing activities    
Proceeds from issuance of SVB Term Loan   10,000,000
Payment of SVB Term loan issuance costs   (45,934)
Proceeds from ATM Offering, net of commissions of $0.3 million 10,665,819 3,830,970
Proceeds from PPP Loan   1,717,000
Proceeds from Series A convertible preferred stock in private placement   562,955
Payments on NuvoGen obligation (254,979) (421,525)
Proceeds from exercise of pre-funded warrants   31,768
Proceeds from shares purchased under stock purchase plans 53,437 25,133
Payments on financing leases (12,694) (22,845)
Proceeds from exercise of stock options 326  
Taxes paid for net share settlement of restricted stock awards (1,892) (9,160)
Payments on 2021 and 2020 Insurance Notes (247,047) (80,710)
Net cash provided by financing activities 10,202,970 5,149,029
Effect of exchange rates on cash (7,464) 3,805
Decrease (increase) in cash, cash equivalents and restricted cash (8,821,367) 10,124,380
Cash, cash equivalents and restricted cash at beginning of period 22,397,812 10,889,995
Cash, cash equivalents and restricted cash at end of period 13,576,445 21,014,375
Supplemental disclosure of noncash investing and financing activities    
Fixed asset purchases payable and accrued at period end 41,864  
Issuance of Series A convertible preferred stock in exchange for outstanding common stock   2,424,900
Issuance of common stock upon conversion of Series A convertible preferred stock   1,622,500
Issuance of common stock from cashless exercise of pre-funded warrants 145  
Operating lease right-of-use assets obtained in exchange for operating lease liabilities   21,078
SVB Term Loan costs payable and accrued at period end   60,710
2021 and 2020 Insurance Notes issued for insurance premiums 746,360 735,195
Gain on forgiveness of PPP Loan 1,735,792  
Supplemental cash flow information    
Cash paid for interest 296,835 602,200
Cash paid for taxes $ 12,665 6,581
QNAH Convertible Note    
Financing activities    
Payments for extinguishment of debt   (3,000,000)
MidCap Credit Facility    
Financing activities    
Payments for extinguishment of debt   $ (7,438,623)