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Condensed Consolidated Statements of Cash Flows - USD ($)
3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Operating activities    
Net loss $ (4,848,307) $ (5,457,898)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 197,951 348,633
Accretion of discount on NuvoGen obligation (3,106) (3,430)
Provision for excess inventory 4,836 6,947
Amortization of QNAH Convertible Note issuance costs   3,364
Amortization of MidCap Credit Facility discount and issuance costs   42,441
Amortization of SVB Term Loan discount and issuance costs 123,010  
Stock-based compensation expense 337,824 415,292
Employee stock purchase plan expense 13,115 5,379
Non-cash operating lease expense 151,831 151,726
Accrued interest on available-for-sale securities investments (3,600) (74,101)
Loss on abandonment and disposal of assets, net 178,925 49,226
Changes in operating assets and liabilities:    
Accounts receivable 56,997 1,961,707
Inventory (115,584) (375,178)
Prepaid expenses and other (401,597) 139,508
Deferred offering costs   140,320
Accounts payable 145,309 (410,806)
Accrued liabilities (336,973) (668,667)
Contract liabilities 302,357 (18,794)
Operating lease liabilities (156,249) (186,220)
Net cash used in operating activities (4,353,261) (3,930,551)
Investing activities    
Purchase of property and equipment (98,509) (25,231)
Maturities of available-for-sale securities 6,300,000 8,250,000
Purchase of available-for-sale securities (8,986,169) (4,272,298)
Net cash provided by (used in) investing activities (2,784,678) 3,952,471
Financing activities    
Proceeds from ATM Offering, net of commissions of $0.2 million 6,855,198 2,435,912
Proceeds from Series A convertible preferred stock in private placement   600,030
Payments on NuvoGen obligation (154,777) (287,997)
Proceeds from exercise of pre-funded warrants   31,768
Payments on financing leases (6,905) (11,833)
Proceeds from exercise of stock options 326  
Taxes paid for net share settlement of restricted stock awards (1,197) (7,052)
Payments on Insurance Note (165,099)  
Net cash provided by financing activities 6,527,546 2,760,828
Effect of exchange rates on cash (9,732) 1,201
Increase (decrease) in cash, cash equivalents and restricted cash (620,125) 2,783,949
Cash, cash equivalents and restricted cash at beginning of period 22,397,812 10,889,995
Cash, cash equivalents and restricted cash at end of period 21,777,687 13,673,944
Supplemental disclosure of noncash investing and financing activities    
Fixed asset purchases payable and accrued at period end 10,738 289,838
Issuance of Series A convertible preferred stock in exchange for outstanding common stock   2,424,900
Series A convertible preferred stock in private placement, costs payable and accrued at period end   37,075
Issuance of common stock in connection with LP Purchase Agreement   615
LP Purchase Agreement, costs payable and accrued at period end   96,000
Supplemental cash flow information    
Cash paid for interest 146,161 $ 164,005
Cash paid for taxes $ 90