Condensed Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Total	LP Purchase Agreement	ATM Offering	Private Placement	Series A Convertible Preferred Stock	Series A Convertible Preferred Stock Private Placement	Common Stock	Common Stock LP Purchase Agreement	Common Stock ATM Offering	Additional Paid-In Capital	Additional Paid-In Capital LP Purchase Agreement	Additional Paid-In Capital ATM Offering	Additional Paid-In Capital Private Placement	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Balance at Dec. 31, 2019	$ 23,969,634						$ 3,873			$ 194,288,368				$ (4,964)	$ (170,317,643)
Balance, shares at Dec. 31, 2019							3,872,682
Stock-based compensation expense	415,256									415,256
Release of restricted stock awards	36						$ 2			34
Release of restricted stock awards, shares							2,396
Net share settlement of restricted stock award	(7,052)						$ (1)			(7,051)
Net share settlement of restricted stock award, shares							(751)
Employee stock purchase plan expense	5,379									5,379
Issuance of preferred stock	2,424,900			$ 562,955	$ 41	$ 10				2,424,859			$ 562,945
Issuance of preferred stock, shares					41,100	10,170
Issuance of common stock	2,435,912						$ 293	$ 41		2,435,619	$ (41)
Issuance of common stock, shares							293,271	41,026
Cancellation of common stock received in exchange for Series A convertible preferred stock	(2,424,900)						$ (274)			(2,424,626)
Cancellation of common stock received in exchange for Series A convertible preferred stock, shares							(274,000)
Exercise of pre-funded warrants	31,768						$ 212			31,556
Exercise of pre-funded warrants, shares							211,784
Adjustment in connection with LP Purchase Agreement commitment fee and transaction costs		$ (96,000)									$ (96,000)
Net loss	(5,457,898)														(5,457,898)
Unrealized gain on short-term investments	47,697													47,697
Foreign currency translation adjustment	5,497													5,497
Balance at Mar. 31, 2020	21,913,184				$ 51		$ 4,146			197,636,298				48,230	(175,775,541)
Balance, shares at Mar. 31, 2020					51,270		4,146,408
Balance at Dec. 31, 2020	14,484,660				$ 24		$ 5,200			205,661,999				5,298	(191,187,861)
Balance, shares at Dec. 31, 2020					23,770		5,199,997
Stock-based compensation expense	337,823									337,823
Release of restricted stock awards	1						$ 1
Release of restricted stock awards, shares							1,390
Net share settlement of restricted stock award	(1,197)									(1,197)
Net share settlement of restricted stock award, shares							(250)
Employee stock purchase plan expense	13,115									13,115
Issuance of common stock			$ 6,855,198						$ 1,058			$ 6,854,140
Issuance of common stock, shares									1,058,045
Exercise of stock options	326									326
Exercise of stock options, shares							75
Net loss	(4,848,307)														(4,848,307)
Unrealized gain on short-term investments	0
Foreign currency translation adjustment	(1,557)													(1,557)
Balance at Mar. 31, 2021	$ 16,840,062				$ 24		$ 6,259			$ 212,866,206				$ 3,741	$ (196,036,168)
Balance, shares at Mar. 31, 2021					23,770		6,259,257