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Condensed Consolidated Statements of Cash Flows - USD ($)
9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Operating activities    
Net loss $ (16,580,237) $ (14,908,348)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,039,989 920,863
Accretion of discount on NuvoGen obligation (9,771) (10,273)
Provision for excess inventory 5,649 126,582
Write-off of Cowen ATM offering costs   108,883
Amortization of QNAH Convertible Note issuance costs 6,505 10,091
Amortization of MidCap Credit Facility discount and issuance costs 101,482 128,476
Amortization of SVB Term Loan discount and issuance costs 121,168  
Stock-based compensation expense 1,163,742 845,133
Employee stock purchase plan expense 15,972 49,914
Non-cash operating lease expense 465,504 329,248
Accrued interest on available-for-sale securities investments (101,996) (231,272)
Issuance of common stock in connection with LP Purchase Agreement 205,538  
Loss on extinguishment of Midcap Credit Facility and QNAH Convertible Note 522,394  
Loss on abandonment and disposal of assets, net 77,498  
Changes in operating assets and liabilities:    
Accounts receivable 1,793,975 1,079,317
Inventory (255,718) (11,715)
Prepaid expenses and other 457,504 (383,643)
Deferred offering costs 140,320  
Accounts payable (778,706) 928,454
Accrued liabilities (474,521) (1,526,835)
Contract liabilities (74,700) 152,681
Operating lease liabilities (583,828) (446,403)
Net cash used in operating activities (12,742,237) (12,838,847)
Investing activities    
Purchase of property and equipment (418,712) (753,430)
Maturities of available-for-sale securities 25,450,000 30,800,000
Purchase of available-for-sale securities (11,565,882) (10,922,764)
Net cash provided by investing activities 13,465,406 19,123,806
Financing activities    
Proceeds from issuance of SVB Term Loan and common stock warrants 10,000,000  
Payment of SVB Term Loan issuance costs (115,193)  
Proceeds from 2019 underwritten public and private offerings, net of underwriting discounts, commissions and costs of $1.7 million   21,102,077
Proceeds from ATM Offering, net 6,387,982  
Proceeds from PPP Loan 1,717,000  
Proceeds from Series A convertible preferred stock in private placement 562,955  
Payments on NuvoGen obligation (539,323) (1,003,634)
Proceeds from exercise of pre-funded warrants 31,768  
Proceeds from shares purchased under stock purchase plans 25,133 82,345
Proceeds from exercise of stock options   120,954
Payments on financing leases (32,553) (34,928)
Taxes paid for net share settlement of restricted stock awards (12,824) (28,067)
Payment of deferred offering costs   (139,058)
Payments on Insurance Note (324,301)  
Net cash provided by financing activities 7,262,021 20,099,689
Effect of exchange rates on cash 9,283 29,838
Increase in cash, cash equivalents and restricted cash 7,994,473 26,414,486
Cash, cash equivalents and restricted cash at beginning of period 10,889,995 11,702,847
Cash, cash equivalents and restricted cash at end of period 18,884,468 38,117,333
Supplemental disclosure of noncash investing and financing activities    
Issuance of Series A convertible preferred stock in exchange for outstanding common stock 2,424,900  
Issuance of Common stock in exchange for Series A convertible preferred stock 1,622,500  
Adoption of ASC 842, Leases   694,352
Operating lease right-of-use assets obtained in exchange for operating lease liabilities 21,078 1,005,085
Carrying value of demonstration units transferred from property and equipment to inventory 18,817  
Fixed asset purchases payable and accrued at period end   21,381
Offering costs payable and accrued at period end   276,694
Supplemental cash flow information    
Cash paid for interest 719,676 521,538
Cash paid for taxes 9,961 $ 3,170
QNAH Convertible Note    
Financing activities    
Payments for extinguishment of debt (3,000,000)  
MidCap Credit Facility    
Financing activities    
Payments for extinguishment of debt $ (7,438,623)