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Condensed Consolidated Statements of Cash Flows - USD ($)
6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Operating activities    
Net loss $ (11,168,449) $ (10,168,116)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 700,276 603,480
Accretion of discount on NuvoGen obligation (6,656) (6,483)
Provision for excess inventory 1,672 45,000
Amortization of QNAH Convertible Note issuance costs 6,505 6,727
Amortization of MidCap Credit Facility discount and issuance costs 101,482 81,096
Amortization of SVB Term Loan discount and issuance costs 3,389  
Stock-based compensation expense 776,793 528,578
Employee stock purchase plan expense 10,758 33,589
Non-cash operating lease expense 306,230 194,232
Accrued interest on available-for-sale securities investments (98,092) (178,165)
Issuance of common stock in connection with LP Purchase Agreement 205,538  
Loss on extinguishment of Midcap Credit Facility and QNAH Convertible Note 522,394  
Loss on abandonment of assets 49,226  
Changes in operating assets and liabilities:    
Accounts receivable 2,152,714 1,031,575
Inventory (120,575) 100,927
Prepaid expenses and other 171,774 (501,474)
Deferred offering costs 140,320  
Accounts payable (659,736) 1,172,992
Accrued liabilities (1,047,223) (1,784,860)
Contract liabilities (53,284) 344,494
Operating lease liabilities (378,840) (270,477)
Net cash used in operating activities (8,383,784) (8,766,885)
Investing activities    
Purchase of property and equipment (322,372) (319,425)
Sales, redemptions and maturities of available-for-sale securities 17,950,000 22,400,000
Purchase of available-for-sale securities (4,272,298) (9,290,341)
Net cash provided by investing activities 13,355,330 12,790,234
Financing activities    
Proceeds from issuance of SVB Term Loan and common stock warrants 10,000,000  
Payment of SVB Term Loan issuance costs (45,934)  
Proceeds from ATM Offering, net 3,830,970  
Proceeds from PPP Loan 1,717,000  
Proceeds from Series A convertible preferred stock in private placement 562,955  
Payments on NuvoGen obligation (421,525) (655,855)
Proceeds from exercise of pre-funded warrants 31,768  
Proceeds from shares purchased under stock purchase plans 25,133 82,345
Proceeds from exercise of stock options   120,954
Payments on financing leases (22,845) (25,227)
Taxes paid for net share settlement of restricted stock awards (9,160) (20,837)
Payment of deferred offering costs   (139,058)
Payments on Insurance Note (80,710)  
Net cash provided by (used in) financing activities 5,149,029 (637,678)
Effect of exchange rates on cash 3,805 (4,682)
Increase in cash, cash equivalents and restricted cash 10,124,380 3,380,989
Cash, cash equivalents and restricted cash at beginning of period 10,889,995 11,702,847
Cash, cash equivalents and restricted cash at end of period 21,014,375 15,083,836
Supplemental disclosure of noncash investing and financing activities    
Issuance of Series A convertible preferred stock in exchange for outstanding common stock 2,424,900  
Issuance of Common stock in exchange for Series A convertible preferred stock 1,622,500  
Adoption of ASC 842, Leases   694,352
Operating lease right-of-use assets obtained in exchange for operating lease liabilities 21,078 894,544
Fixed asset purchases payable and accrued at period end   374,202
SVB Term Loan costs payable and accrued at period end 60,710  
Supplemental cash flow information    
Cash paid for interest 602,200 348,130
Cash paid for taxes 6,581 $ 6,848
QNAH Convertible Note    
Financing activities    
Payments for extinguishment of debt (3,000,000)  
MidCap Credit Facility    
Financing activities    
Payments for extinguishment of debt $ (7,438,623)