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Condensed Consolidated Statements of Changes in Stockholders' Equity - USD ($)
Total
LP Purchase Agreement
ATM Offering
Private Placement
Series A Convertible Preferred Stock
Series A Convertible Preferred Stock
Private Placement
Common Stock
Common Stock
LP Purchase Agreement
Common Stock
ATM Offering
Additional Paid-In Capital
Additional Paid-In Capital
LP Purchase Agreement
Additional Paid-In Capital
ATM Offering
Additional Paid-In Capital
Private Placement
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2018 $ 21,092,062           $ 28,585     $ 172,086,909       $ (3,453) $ (151,019,979)
Balance, shares at Dec. 31, 2018             28,585,449                
Exercise of stock options 51,570           $ 22     51,548          
Exercise of stock options, shares             21,871                
Stock-based compensation expense 241,233                 241,233          
Release of restricted stock awards 13           $ 13                
Release of restricted stock awards, shares             13,126                
Net share settlement of restricted stock award (9,685)           $ (4)     (9,681)          
Net share settlement of restricted stock award, shares             (3,813)                
Employee stock purchase plan expense 16,794                 16,794          
Net loss (5,370,846)                           (5,370,846)
Unrealized gain (loss) on short-term investments 3,353                         3,353  
Foreign currency translation adjustment 6,439                         6,439  
Balance at Mar. 31, 2019 16,030,933           $ 28,616     172,386,803       6,339 (156,390,825)
Balance, shares at Mar. 31, 2019             28,616,633                
Balance at Dec. 31, 2018 21,092,062           $ 28,585     172,086,909       (3,453) (151,019,979)
Balance, shares at Dec. 31, 2018             28,585,449                
Net loss (10,168,116)                            
Unrealized gain (loss) on short-term investments 4,172                            
Balance at Jun. 30, 2019 11,669,992           $ 28,707     172,831,416       (2,036) (161,188,095)
Balance, shares at Jun. 30, 2019             28,707,047                
Balance at Mar. 31, 2019 16,030,933           $ 28,616     172,386,803       6,339 (156,390,825)
Balance, shares at Mar. 31, 2019             28,616,633                
Exercise of stock options 69,384           $ 32     69,352          
Exercise of stock options, shares             32,385                
Stock-based compensation expense 287,317                 287,317          
Release of restricted stock awards 15           $ 15                
Release of restricted stock awards, shares             15,001                
Net share settlement of restricted stock award (11,152)           $ (4)     (11,148)          
Net share settlement of restricted stock award, shares             (4,461)                
Stock issued under stock purchase plans 99,140           $ 48     99,092          
Stock issued under stock purchase plans, shares             47,489                
Net loss (4,797,270)                           (4,797,270)
Unrealized gain (loss) on short-term investments 819                         819  
Foreign currency translation adjustment (9,194)                         (9,194)  
Balance at Jun. 30, 2019 11,669,992           $ 28,707     172,831,416       (2,036) (161,188,095)
Balance, shares at Jun. 30, 2019             28,707,047                
Balance at Dec. 31, 2019 23,969,634           $ 58,090     194,234,151       (4,964) (170,317,643)
Balance, shares at Dec. 31, 2019             58,090,233                
Stock-based compensation expense 415,256                 415,256          
Release of restricted stock awards 36           $ 36                
Release of restricted stock awards, shares             35,942                
Net share settlement of restricted stock award (7,052)           $ (11)     (7,041)          
Net share settlement of restricted stock award, shares             (11,266)                
Employee stock purchase plan expense 5,379                 5,379          
Issuance of common stock     $ 2,435,912         $ 615 $ 4,399   $ (615) $ 2,431,513      
Issuance of common stock, shares               615,384 4,399,062            
Issuance of preferred stock 2,424,900     $ 562,955 $ 41 $ 10       2,424,859     $ 562,945    
Issuance of preferred stock, shares         41,100 10,170                  
Cancellation of common stock received in exchange for Series A convertible preferred stock (2,424,900)           $ (4,110)     (2,420,790)          
Cancellation of common stock received in exchange for Series A convertible preferred stock, shares             (4,110,000)                
Exercise of pre-funded warrants 31,768           $ 3,177     28,591          
Exercise of pre-funded warrants, shares             3,176,762                
Adjustment in connection with LP Purchase Agreement commitment fee and transaction costs   $ (96,000)                 (96,000)        
Net loss (5,457,898)                           (5,457,898)
Unrealized gain (loss) on short-term investments 47,697                         47,697  
Foreign currency translation adjustment 5,497                         5,497  
Balance at Mar. 31, 2020 21,913,184       $ 51   $ 62,196     197,578,248       48,230 (175,775,541)
Balance, shares at Mar. 31, 2020         51,270   62,196,117                
Balance at Dec. 31, 2019 23,969,634           $ 58,090     194,234,151       (4,964) (170,317,643)
Balance, shares at Dec. 31, 2019             58,090,233                
Issuance of common stock, shares                 6,483,776            
Net loss (11,168,449)                            
Unrealized gain (loss) on short-term investments 21,561                            
Balance at Jun. 30, 2020 18,683,907       $ 24   $ 67,093     200,079,879       23,003 (181,486,092)
Balance, shares at Jun. 30, 2020         23,770   67,093,683                
Balance at Mar. 31, 2020 21,913,184       $ 51   $ 62,196     197,578,248       48,230 (175,775,541)
Balance, shares at Mar. 31, 2020         51,270   62,196,117                
Stock-based compensation expense 361,477                 361,477          
Release of restricted stock awards 24           $ 24                
Release of restricted stock awards, shares             23,751                
Net share settlement of restricted stock award (2,108)           $ (7)     (2,101)          
Net share settlement of restricted stock award, shares             (6,389)                
Stock issued under stock purchase plans 30,512           $ 45     30,467          
Stock issued under stock purchase plans, shares             45,490                
Issuance of common stock     $ 1,395,058           $ 2,085     $ 1,392,973      
Issuance of common stock, shares                 2,084,714            
Conversion of Series A convertible preferred stock for common stock         $ (27)   $ 2,750     (2,723)          
Conversion of Series A convertible preferred stock for common stock, shares         (27,500)   2,750,000                
Adjustment in connection with LP Purchase Agreement commitment fee and transaction costs   $ 301,538                 $ 301,538        
Issuance of common stock warrants in connection with SVB Term Loan 420,000                 420,000          
Net loss (5,710,551)                           (5,710,551)
Unrealized gain (loss) on short-term investments (26,136)                         (26,136)  
Foreign currency translation adjustment 909                         909  
Balance at Jun. 30, 2020 $ 18,683,907       $ 24   $ 67,093     $ 200,079,879       $ 23,003 $ (181,486,092)
Balance, shares at Jun. 30, 2020         23,770   67,093,683