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Consolidated Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Operating activities    
Net loss $ (19,297,664) $ (16,453,918)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,259,015 1,468,121
Accretion of discount on NuvoGen obligation (13,821) (12,480)
Provision for excess inventory 153,729 83,218
Amortization of Growth Term Loan discount and issuance costs   62,951
Loss on extinguishment of Growth Term Loan   105,064
Write-off of ATM offering costs 108,883  
Amortization of QNAH Convertible Note issuance costs 13,454 13,453
Amortization of MidCap Credit Facility discount and issuance costs 183,002 133,963
Stock-based compensation expense 1,156,567 1,888,055
Employee stock purchase plan expense 66,238 58,959
Amortization of operating lease right-of-use assets 476,789  
Amortization of incentive from landlord   (142,000)
Accrued interest on available-for-sale securities investments (325,666) (412,436)
Loss on disposal of assets 9,051 8,104
Changes in operating assets and liabilities:    
Accounts receivable 1,848,502 1,332,030
Inventory (116,787) (171,909)
Prepaid expenses and other (177,307) (113,581)
Deferred offering costs   2,953
Accounts payable (155,974) (150,176)
Accrued liabilities (1,440,065) (447,351)
Contract liabilities 188,507 (426,938)
Operating lease liabilities (632,389)  
Net cash used in operating activities (16,695,936) (13,173,918)
Investing activities    
Purchase of property and equipment (1,103,176) (949,514)
Sales, redemptions and maturities of available-for-sale securities 32,200,000 31,700,000
Purchase of available-for-sale securities (34,601,208) (53,970,921)
Net cash used in investing activities (3,504,384) (23,220,435)
Financing activities    
Proceeds from MidCap Credit Facility   7,000,000
MidCap Credit Facility lender fees   (422,390)
Payments on Growth Term Loan   (1,684,626)
Payments for extinguishment of Growth Term Loan   (4,276,988)
Proceeds from 2018 underwritten public offering, net of underwriting discounts, commissions and issuance costs of $2.6 million   37,724,316
Proceeds from 2019 underwritten public and private offerings, net of underwriting discounts, commissions and issuance costs of $1.7 million 20,758,940  
Proceeds from ATM Offering, net   556,706
Payments on NuvoGen obligation (1,327,922) (1,012,122)
Payments on financing leases (44,043) (62,085)
Proceeds from exercise of stock options 120,954 316,767
Taxes paid for net share settlement of restricted stock awards (30,904) (150,748)
Proceeds from shares purchased under stock purchase plans 104,952 140,915
Payment of deferred offering costs (190,173)  
Net cash provided by financing activities 19,391,804 38,129,745
Effect of exchange rates on cash (4,336) (1,145)
(Decrease) increase in cash, cash equivalents and restricted cash (812,852) 1,734,247
Cash, cash equivalents and restricted cash at beginning of year 11,702,847 9,968,600
Cash, cash equivalents and restricted cash at end of year 10,889,995 11,702,847
Supplemental disclosure of noncash investing and financing activities    
Fixed asset purchases payable and accrued at period end 8,299 39,265
Adoption of ASC 842, Leases 694,352  
Operating lease right-of-use assets obtained in exchange for operating lease liabilities 1,005,085  
Financing lease right-of-use assets obtained in exchange for financing lease liabilities 63,406  
Equipment purchased through capital leases   71,709
Carrying value of demonstration units transferred from property and equipment to inventory   49,245
Debt issuance costs payable and accrued at period end   59,030
MidCap Term Loan fees and warrant discount   389,000
Supplemental cash flow information    
Cash paid for interest 686,042 553,070
Cash paid for taxes $ 3,379 $ 3,545