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Condensed Consolidated Statements of Cash Flows - USD ($)
9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Operating activities    
Net loss $ (14,908,348) $ (14,326,084)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 920,863 1,126,230
Accretion of discount on NuvoGen obligation (10,273) (9,125)
Provision for excess inventory 126,582 63,840
Amortization of Growth Term Loan discount and issuance costs   62,951
Loss on extinguishment of Growth Term Loan   105,064
Write-off of ATM offering costs 108,883  
Amortization of QNAH Convertible Note issuance costs 10,091 10,090
Amortization of MidCap Credit Facility discount and issuance costs 128,476 92,060
Stock-based compensation expense 845,133 1,643,353
Employee stock purchase plan expense 49,914 43,932
Amortization of operating lease right-of-use assets 329,248  
Amortization of incentive from landlord   (106,500)
Accrued interest on available-for-sale securities investments (231,272) (292,308)
Changes in operating assets and liabilities:    
Accounts receivable 1,079,317 2,994,935
Inventory (11,715) 24,986
Prepaid expenses and other (383,643) (245,488)
Deferred offering costs   2,953
Accounts payable 928,454 (123,266)
Accrued liabilities (1,526,835) (1,216,171)
Contract liabilities 152,681 (449,911)
Operating lease liabilities (446,403)  
Net cash used in operating activities (12,838,847) (10,598,459)
Investing activities    
Purchase of property and equipment (753,430) (857,899)
Sales, redemptions and maturities of available-for-sale securities 30,800,000 15,800,000
Purchase of available-for-sale securities (10,922,764) (43,129,605)
Net cash provided by (used in) investing activities 19,123,806 (28,187,504)
Financing activities    
Proceeds from MidCap Credit Facility   7,000,000
MidCap Credit Facility lender fees   (422,390)
Payments on Growth Term Loan   (1,684,626)
Payments for extinguishment of Growth Term Loan   (4,276,988)
Proceeds from 2018 underwritten public offering, net of underwriting discounts, commissions and costs of $2.6 million   37,724,316
Proceeds from 2019 underwritten public and private offerings, net of underwriting discounts, commissions and costs of $1.7 million 21,102,077  
Proceeds from ATM Offering, net   556,706
Payments on NuvoGen obligation (1,003,634) (729,739)
Payments on financing leases (34,928) (59,186)
Proceeds from exercise of stock options 120,954 204,173
Taxes paid for net share settlement of restricted stock awards (28,067) (133,513)
Proceeds from shares purchased under stock purchase plans 82,345 72,862
Payment of deferred offering costs (139,058)  
Net cash provided by financing activities 20,099,689 38,251,615
Effect of exchange rates on cash 29,838  
Increase (decrease) in cash, cash equivalents and restricted cash 26,414,486 (534,348)
Cash, cash equivalents and restricted cash at beginning of period 11,702,847 9,968,600
Cash, cash equivalents and restricted cash at end of period 38,117,333 9,434,252
Supplemental disclosure of noncash investing and financing activities    
Fixed asset purchases payable and accrued at period end 21,381 29,615
Adoption of ASC 842, Leases 694,352  
Operating lease right-of-use assets obtained in exchange for operating lease liabilities 1,005,085  
Offering costs payable and accrued at period end 276,694  
Equipment purchased through capital leases   63,809
Carrying value of demonstration units transferred from property and equipment to inventory   49,245
MidCap Term Loan fees and warrant discount   389,000
Supplemental cash flow information    
Cash paid for interest 521,538 369,360
Cash paid for taxes $ 3,170 $ 3,545