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Condensed Consolidated Statements of Cash Flows - USD ($)
6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Operating activities    
Net loss $ (10,168,116) $ (9,482,676)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 603,480 778,344
Accretion of discount on NuvoGen obligation (6,483) (6,006)
Provision for excess inventory 45,000 23,533
Amortization of Growth Term Loan discount and issuance costs   62,951
Loss on extinguishment of Growth Term Loan   105,064
Amortization of QNAH Convertible Note issuance costs 6,727 6,727
Amortization of MidCap Credit Facility discount and issuance costs 81,096 48,092
Stock-based compensation expense 528,578 1,385,378
Employee stock purchase plan expense 33,589 28,906
Amortization of operating lease right-of-use assets 194,232  
Amortization of incentive from landlord   (71,000)
Accrued interest on available-for-sale securities investments (178,165) (187,946)
Changes in operating assets and liabilities:    
Accounts receivable 1,031,575 2,874,274
Inventory 100,927 191,836
Prepaid expenses and other (501,474) (402,102)
Deferred offering costs   2,953
Accounts payable 1,172,992 (656,645)
Accrued liabilities (1,784,860) (1,319,010)
Contract liabilities 344,494 (389,172)
Operating lease liabilities (270,477)  
Net cash used in operating activities (8,766,885) (7,006,499)
Investing activities    
Purchase of property and equipment (319,425) (829,186)
Sales, redemptions and maturities of available-for-sale securities 22,400,000 3,300,000
Purchase of available-for-sale securities (9,290,341) (38,079,329)
Net cash provided by (used in) investing activities 12,790,234 (35,608,515)
Financing activities    
Proceeds from MidCap Credit Facility   7,000,000
MidCap Credit Facility lender fees   (422,390)
Payments on Growth Term Loan   (1,684,626)
Payments for extinguishment of Growth Term Loan   (4,276,988)
Proceeds from public offering, net of underwriting discounts, commissions and costs of $2.6 million   37,724,316
Proceeds from ATM Offering, net   556,706
Payments on NuvoGen obligation (655,855) (435,093)
Payments on financing leases (25,227) (40,017)
Proceeds from exercise of stock options 120,954 69,513
Taxes paid for net share settlement of restricted stock awards (20,837) (133,513)
Proceeds from shares purchased under stock purchase plans 82,345 62,862
Payment of deferred offering costs (139,058)  
Net cash (used in) provided by financing activities (637,678) 38,420,770
Effect of exchange rates on cash (4,682)  
Increase (decrease) in cash, cash equivalents and restricted cash 3,380,989 (4,194,244)
Cash, cash equivalents and restricted cash at beginning of period 11,702,847 9,968,600
Cash, cash equivalents and restricted cash at end of period 15,083,836 5,774,356
Supplemental disclosure of noncash investing and financing activities    
Fixed asset purchases payable and accrued at period end 374,202 2,730
Adoption of ASC 842, Leases 694,352  
Operating lease right-of-use assets obtained in exchange for operating lease liabilities 894,544  
Equipment purchased through capital leases   45,896
Carrying value of demonstration units transferred from property and equipment to inventory   49,245
MidCap Term Loan fees and warrant discount   389,000
Supplemental cash flow information    
Cash paid for interest 348,130 202,573
Cash paid for taxes $ 6,848 $ 3,545