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Consolidated Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Operating activities    
Net loss $ (16,453,918) $ (18,960,017)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,468,121 1,241,873
Accretion of discount on NuvoGen obligation (12,480) 195,248
Provision for excess inventory 83,218 366,963
Amortization of Growth Term Loan discount and issuance costs 62,951 404,462
Loss on extinguishment of Growth Term Loan 105,064  
Amortization of QNAH Convertible Note issuance costs 13,453 1,269
Amortization of MidCap Credit Facility discount and issuance costs 133,963  
Stock-based compensation expense 1,888,055 1,376,969
Employee stock purchase plan expense 58,959 59,118
Accretion of incentive from landlord (142,000) (142,000)
Accrued interest on available-for-sale securities investments (412,436)  
Loss on disposal of assets 8,104 81,539
Changes in operating assets and liabilities:    
Accounts receivable 1,332,030 (4,978,827)
Inventory (171,909) 77,176
Prepaid expenses and other (113,581) (3,749)
Deferred offering costs 2,953 49,630
Accounts payable (150,176) 1,225,954
Accrued liabilities (447,351) 2,076,500
Contract liabilities (426,938) 355,584
Net cash used in operating activities (13,173,918) (16,572,308)
Investing activities    
Purchase of property and equipment (949,514) (1,020,531)
Sales, redemptions and maturities of available-for-sale securities 31,700,000 4,300,000
Purchase of available-for-sale securities (53,970,921)  
Net cash (used in) provided by investing activities (23,220,435) 3,279,469
Financing activities    
Proceeds from MidCap Credit Facility 7,000,000  
MidCap Credit Facility lender fees (422,390)  
Payments on Growth Term Loan (1,684,626) (6,389,782)
Payments for extinguishment of Growth Term Loan (4,276,988)  
Proceeds from public offering, net of underwriting discounts, commissions and costs of $2.6 million 37,724,316 (231,476)
Proceeds from ATM Offering, net 556,706 19,908,954
Proceeds from issuance of convertible note to QNAH, a related party   3,000,000
QNAH Convertible Note financing costs   (40,509)
Payments on NuvoGen obligation (1,012,122) (800,000)
Payments on capital leases (62,085) (69,142)
Proceeds from exercise of stock options 316,767 112,138
Taxes paid for net share settlement of restricted stock awards 140,915  
Proceeds from shares purchased under stock purchase plans   266,549
Payment of deferred offering costs (150,748) (2,952)
Net cash provided by financing activities 38,129,745 15,753,780
Effect of exchange rates on cash (1,145)  
Increase in cash, cash equivalents and restricted cash 1,734,247 2,460,941
Cash and cash equivalents at beginning of year 9,968,600 7,507,659
Cash, cash equivalents and restricted cash at end of year 11,702,847 9,968,600
Supplemental disclosure of noncash investing and financing activities    
Fixed asset purchases payable and accrued at period end 39,265 477,966
Carrying value of demonstration units transferred from property and equipment to inventory 49,245 113,607
Equipment purchased through capital lease 71,709  
Debt issuance costs payable and accrued at period end 59,030  
MidCap Term Loan fees and warrant discount 389,000  
Retirement of treasury stock   75,000
Supplemental cash flow information    
Cash paid for interest 553,070 698,065
Cash paid for taxes $ 3,545 $ 1,967