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Stockholders' Equity - Summary of Stock Option Plans Activity Including Inducement Award Activity (Details) - Employee Stock Option - USD ($)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]      
Number of Shares, Beginning Balance 46,611 40,602  
Number of Shares, Granted 39,667 12,819  
Number of Shares, Exercised   (6)  
Number of Shares, Forfeited (4,944) (4,406)  
Number of Shares, Expired/Cancelled (5,235) (2,398)  
Number of Shares, Ending Balance 76,099 46,611 40,602
Number of Shares, Exercisable 38,096 24,915  
Weighted-Average Exercise Price Per Share, Beginning Balance $ 167.16 $ 201.36  
Weighted-Average Exercise Price Per Share, Granted 12.91 65.40  
Weighted-Average Exercise Price Per Share, Exercised   52.20  
Weighted-Average Exercise Price Per Share, Forfeited 66.58 143.76  
Weighted-Average Exercise Price Per Share, Expired/Cancelled 292.56 244.68  
Weighted-Average Exercise Price Per Share, Ending Balance 84.73 167.16 $ 201.36
Weighted-Average Exercise Price Per Share, Exercisable $ 142.34 $ 241.68  
Weighted-Average Remaining Contractual Life, Outstanding 8 years 3 months 18 days 8 years 2 months 12 days 8 years 7 months 6 days
Weighted-Average Remaining Contractual Life, Exercisable 7 years 7 months 6 days 7 years 4 months 24 days  
Aggregate Intrinsic Value, Balance $ 0 $ 30,267 $ 1,536
Aggregate Intrinsic Value, Exercised   107  
Aggregate Intrinsic Value, Exercisable $ 0 $ 6,269