Stockholders' Equity - Additional Information (Details) - USD ($)		1 Months Ended					12 Months Ended
	Dec. 20, 2022	Dec. 31, 2022	May 31, 2022	Mar. 31, 2022	May 31, 2021	Feb. 29, 2020	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2019	Nov. 29, 2022	Oct. 21, 2022	Aug. 31, 2021	Jul. 31, 2021	Jun. 30, 2021	Dec. 31, 2020	Aug. 31, 2020	Mar. 04, 2020	Nov. 30, 2019	Sep. 30, 2019
Class of Stock [Line Items]
Reverse stock split, description							On December 20, 2022, the Company completed a reverse stock split of its outstanding shares of common stock pursuant to which every 12 shares of issued and outstanding common stock were exchanged for one share of common stock.
Common stock split Price per share	$ 8.20
Fractional shares from reverse stock split share	0
Exercise price of warrants		$ 9.6875					$ 9.6875
Reimbursement of expenses and legal fees							$ 125,000
Common stock, shares outstanding		2,213,897					2,213,897	632,340
Common stock, shares issued		2,213,897					2,213,897	632,340
Common stock, shares authorized		26,666,667					26,666,667	26,666,667
Common stock, par value		$ 0.001					$ 0.001	$ 0.001
Preferred stock, shares authorized		10,000,000					10,000,000
Preferred stock, par value		$ 0.001					$ 0.001
Weighted-average fair value of stock options granted							$ 10.50	$ 52.56
Payments of Stock Issuance Costs							$ 500,000
Employee Stock Option
Class of Stock [Line Items]
Number of Shares, Granted							39,667	12,819
Numbe of Awards Outstanding		76,099					76,099	46,611							40,602
Number of Shares, Forfeited							4,944	4,406
Unrecognized compensation expense		$ 0.8					$ 0.8
Compensation expense period expected to be recognized							1 year 10 months 13 days
Restricted Stock Units R S U
Class of Stock [Line Items]
Number of RSU shares Granted							416	2,500
RSU Awards outstanding (in shares)		1,249					1,249	2,598							1,017
Number of RSU Shares, Forfeited							626	542
Unrecognized compensation expense		$ 41,600					$ 41,600
Compensation expense period expected to be recognized							10 months 28 days
Granted							$ 8.29	$ 62.40
Vested and unissued RSU awards, description							Vested and unissued awards at December 31, 2022 represents RSU awards granted in November 2021 for which a portion of the awards vested on December 31, 2022, but for which issuance of shares occurred in January 2023.
Pre Funded Warrants
Class of Stock [Line Items]
Exercise price of warrants		$ 7.50					$ 7.50
Placement Agent Warrants
Class of Stock [Line Items]
Number of securities called by warrants		38,709					38,709
Placement Agent Warrants | Pre Funded Warrants
Class of Stock [Line Items]
Warrants exercised		1,188,322					1,188,322
Proceeds from exercise of pre-funded warrants		$ 1,188	$ 2,411
ATM Offering
Class of Stock [Line Items]
Issuance of common stock								$ 10,665,819
Net proceeds from issuance of common stock								10,700,000
Payments of Stock Issuance Costs								$ 300,000
Employee Stock Purchase Plan
Class of Stock [Line Items]
Fair market value of company common stock, shares offering price							85.00%
Fair market value of company common stock, shares purchase price							85.00%
Maximum contribution eligible compensation during a period to purchase common stock		15.00%					15.00%
Vested and unissued RSU awards, description							Under the 2014 ESPP, the number of shares of common stock reserved for issuance automatically increased on January 1 of each calendar year, from January 1, 2016 to January 1, 2021 by the lesser of (i) 1% of the total number of shares of the Company’s common stock outstanding on December 31 of the preceding calendar year, (ii) 1,083 shares, or (iii) a number determined by the Company’s Board of Directors that is less than (i) and (ii)
Shares reserved for issuance		35,120					35,120
Public Offering
Class of Stock [Line Items]
Percentage of public offering, cash fee							6.50%
Percentage of public offering, management fee							0.50%
Series A Preferred Stock [Member]
Class of Stock [Line Items]
Preferred stock, par value											$ 0.001
Purchase price of share											$ 100.00
Preferred stock redemption amount										$ 100.00
Institutional Accredited Investors | Placement Agent Warrants
Class of Stock [Line Items]
Exercise price of warrants																			$ 117.00
Institutional Accredited Investors | Placement Agent Warrants | Pre Funded Warrants
Class of Stock [Line Items]
Number of securities called by warrants																			30,064
Exercise price of warrants																			$ 115.20
Exercise price of warrants, exercisable subject to beneficial ownership limitations																			$ 1.80
Warrants exercised			200,911											12,416
Proceeds from exercise of pre-funded warrants					$ 2,411
Cantor Sales Agreement
Class of Stock [Line Items]
Common stock price per share																		$ 0.001
Exchange Agreement
Class of Stock [Line Items]
Common stock, shares outstanding						22,833
Exchange Agreement | Series A Preferred
Class of Stock [Line Items]
Issuance of common stock						$ 600,000
Stock issued, price per share						$ 59.00
Preferred stock, shares outstanding		0		23,770			0
Preferred stock, shares issued						41,100
Preferred stock, par value						$ 0.001
Issuance of common stock, shares						10,170
L P Purchase Agreement | Lincoln Park
Class of Stock [Line Items]
Common stock, shares issued								12,864
Common stock value right to sell, maximum																	$ 20,000,000.0
Common stock weighted average price per share								$ 69.96
Net proceeds from issuance of common stock from the ATM Offering								$ 900,000
December Two Thousand Twenty Two Purchase Agreement [Member]
Class of Stock [Line Items]
Exercise price of warrants		$ 0.001					$ 0.001
Percentage Of Minimum Aggregate Number Of Shares Beneficially Owned By Holder		4.99%
Percentage Increase In Ownership Cap		9.99%
Warrant issuance, description		Each unit consisted of one share of common stock (or one pre-funded warrant in lieu thereof), a common warrant to purchase one share of common stock with a term of 24 months from the issuance date, and a common warrant to purchase one share of common stock with a term of 60 months from the issuance date.
December Two Thousand Twenty Two Purchase Agreement [Member] | Investor
Class of Stock [Line Items]
Number of securities called by warrants		1,290,322					1,290,322
Gross Proceeds From Issuance Of Warrants		$ 8,700,000
Combained Offering Price		$ 7.75					$ 7.75
March Two Thousand Twenty Two Purchase Agreement Member
Class of Stock [Line Items]
Percentage Of Minimum Aggregate Number Of Shares Beneficially Owned By Holder				4.99%
Percentage Increase In Ownership Cap				9.99%
Proceeds from exercise of pre-funded warrants							$ 2,411	0
Warrant issuance, description				Each unit consists of one share of common stock (or one pre-funded warrant in lieu thereof), a common warrant to purchase one share of common stock with a term of 24 months from the issuance date, and a common warrant to purchase one share of common stock with a term of 66 months from the issuance date.
Payments of Stock Issuance Costs							$ 500,000	$ 500,000
March Two Thousand Twenty Two Purchase Agreement Member | Pre Funded Warrants
Class of Stock [Line Items]
Exercise price of warrants				$ 24.744
Percentage Of Minimum Aggregate Number Of Shares Beneficially Owned By Holder				9.99%
March Two Thousand Twenty Two Purchase Agreement Member | Investor
Class of Stock [Line Items]
Number of securities called by warrants				270,415
Exercise price of warrants				$ 27.744
Gross Proceeds From Issuance Of Warrants				$ 7,000,000.0
March Two Thousand Twenty Two Purchase Agreement Member | Investor | Pre Funded Warrants
Class of Stock [Line Items]
Exercise price of warrants				$ 0.012
March Two Thousand Twenty Two Purchase Agreement Member | Investor | Placement Agent Warrants
Class of Stock [Line Items]
Exercise price of warrants		$ 24.744					$ 24.744
March Two Thousand Twenty Two Purchase Agreement Member | Investor | Placement Agent Warrants | Pre Funded Warrants
Class of Stock [Line Items]
Number of securities called by warrants		1,188,322		200,911			1,188,322
Exercise price of warrants		$ 0.001		$ 0.012			$ 0.001
March Two Thousand Twenty Two Purchase Agreement Member | Investor | Placement Agent Warrants | Series A-1 Warrants
Class of Stock [Line Items]
Number of securities called by warrants		1,290,322					1,290,322
Exercise price of warrants		$ 9.6875					$ 9.6875
March Two Thousand Twenty Two Purchase Agreement Member | Investor | Placement Agent Warrants | Series A-2 Warrants
Class of Stock [Line Items]
Number of securities called by warrants		1,290,322					1,290,322
Exercise price of warrants		$ 7.50					$ 7.50
March Two Thousand Twenty Two Purchase Agreement Member | Cantor Fitzgerald And Co
Class of Stock [Line Items]
Agent fee				$ 300,000
Additional transaction costs				$ 200,000
Common Stock
Class of Stock [Line Items]
Reverse stock split, description							In December 2022, the Company completed a reverse stock split of its outstanding shares of common stock pursuant to which every twelve shares of issued and outstanding common stock were exchanged for one share of common stock.
Conversion of Series A convertible preferred stock for common stock, shares							13,206	12,073
Common Stock | ATM Offering
Class of Stock [Line Items]
Issuance of common stock								$ 171
Issuance of common stock, shares								170,907
Common Stock | Exchange Agreement
Class of Stock [Line Items]
Conversion of Series A convertible preferred stock for common stock, shares				13,206
Minimum | December Two Thousand Twenty Two Purchase Agreement [Member] | Investor | Pre Funded Warrants
Class of Stock [Line Items]
Exercise price of warrants		$ 0.001					$ 0.001
Minimum | March Two Thousand Twenty Two Purchase Agreement Member | Investor | Pre Funded Warrants
Class of Stock [Line Items]
Exercise price of warrants				$ 0.012
2021 Inducement Plan | Restricted Stock Units R S U
Class of Stock [Line Items]
Number of RSU shares Granted							416	2,500
Number of RSU Awards released							1,041
RSU Awards outstanding (in shares)		1,249					1,249
Number of RSU Shares, Forfeited							626
2014 Equity Incentive Plan
Class of Stock [Line Items]
Shares reserved for issuance																5,712
Options granted in term									10 years
2014 Equity Incentive Plan | Maximum | Board Of Directors
Class of Stock [Line Items]
Options exercise period									4 years
2020 Equity Incentive Plan
Class of Stock [Line Items]
Shares reserved for issuance																62,057
Number of shares available for issuance		16,668					16,668
2021 Inducement Plan
Class of Stock [Line Items]
Shares reserved for issuance													25,000
Number of shares available for issuance		13,961					13,961
Inducement Awards | Employee Stock Option
Class of Stock [Line Items]
Number of Shares, Granted							3,332	9,166
Numbe of Awards Outstanding		8,748					8,748
Number of Shares, Forfeited							3,750
Amended And Restated Two Thousand Fourteen Employee Stock Purchase Plan [Member]
Class of Stock [Line Items]
Shares reserved for issuance												41,666