Condensed Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Total	Series A Convertible Preferred Stock	Common Stock	Additional Paid-in Capital [Member]	AOCI Attributable to Parent [Member]	Retained Earnings [Member]	Purchase Agreement	Purchase Agreement Common Stock	Purchase Agreement Additional Paid-in Capital [Member]	March Two Thousand Twenty Two Purchase Agreement [Member]	March Two Thousand Twenty Two Purchase Agreement [Member] Common Stock	March Two Thousand Twenty Two Purchase Agreement [Member] Additional Paid-in Capital [Member]	December Two Thousand Twenty Two secuirities purchase agreement [Member]	December Two Thousand Twenty Two secuirities purchase agreement [Member] Common Stock	ATM Offering	ATM Offering Common Stock	ATM Offering Additional Paid-in Capital [Member]	Public Offering [Member]	Public Offering [Member] Common Stock	Public Offering [Member] Additional Paid-in Capital [Member]
Balance at Dec. 31, 2020	$ 14,484,660	$ 24	$ 433	$ 205,666,766	$ 5,298	$ (191,187,861)
Balance, shares at Dec. 31, 2020		23,770	433,333
Stock-based compensation expense	1,317,351			1,317,351
Release of restricted stock awards	4		$ 1	3
Release of restricted stock awards, shares			377
Net share settlement of restricted stock awards	(3,239)			(3,239)
Net share settlement of restricted stock awards, shares			(50)
Employee stock purchase plan expense	57,669			57,669
Stock issued under stock purchase plans	125,828		$ 3	37,560
Stock issued under stock purchase plans, shares			2,830
Conversion of Series A convertible preferred stock for common stock, shares			12,073
Issuance of common stock							$ 899,980	$ 12	$ 899,968						$ 10,665,819	$ 171	$ 10,665,648
Issuance of common stock, shares								12,864								170,907
Exercise of pre-funded warrants			$ 12	(12)
Exercise of pre-funded warrants, shares			12,073
Exercise of stock options	326			326
Exercise of stock options, shares			6
Net loss	(17,145,170)					(17,145,170)
Foreign currency translation adjustment	(3,404)				(3,404)
Balance at Dec. 31, 2021	10,399,824	$ 24	$ 632	218,730,305	1,894	(208,333,031)
Balance, shares at Dec. 31, 2021		23,770	632,340
Stock-based compensation expense	774,160			774,160
Release of restricted stock awards			$ 1	(1)
Release of restricted stock awards, shares			1,139
Net share settlement of restricted stock awards	(11,190)			(11,190)
Net share settlement of restricted stock awards, shares			(355)
Employee stock purchase plan expense	40,347			40,347
Stock issued under stock purchase plans	37,567		$ 7	125,825
Stock issued under stock purchase plans, shares			6,876
Conversion of Series A convertible preferred stock for common stock		$ (24)	$ 13	11
Conversion of Series A convertible preferred stock for common stock, shares		(23,770)	13,206
Issuance of common stock							$ 7,034,049	$ 70	$ 7,033,979									$ 8,707,399	$ 102	$ 8,707,297
Issuance of common stock, shares								69,505											102,000
Exercise of pre-funded warrants										$ 2,411	$ 201	$ 2,210	$ 1,188	$ 1,188
Exercise of pre-funded warrants, shares			1,188,322								200,911
Cash in lieu of fractional shares	(367)			(367)
Cash in lieu of fractional shares, shares			(47)
Net loss	(21,594,476)					(21,594,476)
Foreign currency translation adjustment	785				785
Balance at Dec. 31, 2022	$ 5,391,697	$ 0	$ 2,214	$ 235,314,311	$ 2,679	$ (229,927,507)
Balance, shares at Dec. 31, 2022		0	2,213,897