Condensed Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Total	ATM Offering	Purchase Agreement	Series A Convertible Preferred Stock	Common Stock	Common Stock ATM Offering	Common Stock Purchase Agreement	Additional Paid-In Capital	Additional Paid-In Capital ATM Offering	Additional Paid-In Capital Purchase Agreement	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Balance at Dec. 31, 2020	$ 14,484,660			$ 24	$ 5,200			$ 205,661,999			$ 5,298	$ (191,187,861)
Balance, shares at Dec. 31, 2020				23,770	5,199,997
Stock-based compensation expense	337,823							337,823
Release of restricted stock awards	1				$ 1
Release of restricted stock awards, shares					1,390
Net share settlement of restricted stock awards	(1,197)							(1,197)
Net share settlement of restricted stock award, shares					(250)
Employee stock purchase plan expense	13,115							13,115
Issuance of common stock		$ 6,855,198				$ 1,058			$ 6,854,140
Issuance of common stock, shares						1,058,045
Exercise of stock options	326							326
Exercise of stock options, shares					75
Net loss	(4,848,307)											(4,848,307)
Foreign currency translation adjustment	(1,557)										(1,557)
Balance at Mar. 31, 2021	16,840,062			$ 24	$ 6,259			212,866,206			3,741	(196,036,168)
Balance, shares at Mar. 31, 2021				23,770	6,259,257
Balance at Dec. 31, 2020	14,484,660			$ 24	$ 5,200			205,661,999			5,298	(191,187,861)
Balance, shares at Dec. 31, 2020				23,770	5,199,997
Net loss	(7,463,259)
Unrealized loss on short-term investments	0
Balance at Jun. 30, 2021	18,440,814			$ 24	$ 7,411			217,080,903			3,596	(198,651,120)
Balance, shares at Jun. 30, 2021				23,770	7,411,474
Balance at Mar. 31, 2021	16,840,062			$ 24	$ 6,259			212,866,206			3,741	(196,036,168)
Balance, shares at Mar. 31, 2021				23,770	6,259,257
Stock-based compensation expense	339,369							339,369
Release of restricted stock awards	1				$ 1
Release of restricted stock awards, shares					992
Net share settlement of restricted stock awards	(695)							(695)
Net share settlement of restricted stock award, shares					(127)
Employee stock purchase plan expense	13,116							13,116
Stock issued under stock purchase plans	53,437				$ 13			53,424
Stock issued under stock purchase plans, shares					13,637
Issuance of common stock	3,810,621				$ 993			3,809,628
Issuance of common stock, shares					992,834
Exercise of pre-funded warrants					$ 145			(145)
Exercise of pre-funded warrants, shares					144,881
Net loss	(2,614,952)	$ (2,614,952)										(2,614,952)
Unrealized loss on short-term investments	0
Foreign currency translation adjustment	(145)										(145)
Balance at Jun. 30, 2021	18,440,814			$ 24	$ 7,411			217,080,903			3,596	(198,651,120)
Balance, shares at Jun. 30, 2021				23,770	7,411,474
Balance at Dec. 31, 2021	10,399,824			$ 24	$ 7,588			218,723,349			1,894	(208,333,031)
Balance, shares at Dec. 31, 2021				23,770	7,588,085
Stock-based compensation expense	251,214							251,214
Release of restricted stock awards					$ 4			(4)
Release of restricted stock awards, shares					4,148
Net share settlement of restricted stock awards	(8,129)				$ (1)			(8,128)
Net share settlement of restricted stock award, shares					(1,500)
Employee stock purchase plan expense	16,591							16,591
Issuance of common stock			$ 7,108,786				$ 834			$ 7,107,952
Issuance of common stock, shares							834,054
Conversion of Series A convertible preferred stock for common stock				$ (24)	$ 158			(134)
Conversion of Series A convertible preferred stock for common stock, shares				(23,770)	158,466
Net loss	(6,497,519)											(6,497,519)
Foreign currency translation adjustment	(2,293)										(2,293)
Balance at Mar. 31, 2022	11,268,474				$ 8,583			226,090,840			(399)	(214,830,550)
Balance, shares at Mar. 31, 2022					8,583,253
Balance at Dec. 31, 2021	10,399,824			$ 24	$ 7,588			218,723,349			1,894	(208,333,031)
Balance, shares at Dec. 31, 2021				23,770	7,588,085
Net loss	(12,385,728)
Unrealized loss on short-term investments	(12,214)
Balance at Jun. 30, 2022	5,569,689				$ 11,046			226,293,112			(15,710)	(220,718,759)
Balance, shares at Jun. 30, 2022					11,045,986
Balance at Mar. 31, 2022	11,268,474				$ 8,583			226,090,840			(399)	(214,830,550)
Balance, shares at Mar. 31, 2022					8,583,253
Stock-based compensation expense	214,742							214,742
Release of restricted stock awards					$ 4			(4)
Release of restricted stock awards, shares					4,148
Net share settlement of restricted stock awards	(1,885)				$ (1)			(1,884)
Net share settlement of restricted stock award, shares					(1,355)
Employee stock purchase plan expense	16,592							16,592
Stock issued under stock purchase plans	23,327				$ 49			23,278
Stock issued under stock purchase plans, shares					49,007
Issuance of common stock			$ (50,452)							$ (50,452)
Exercise of pre-funded warrants	2,411				$ 2,411
Exercise of pre-funded warrants, shares					2,410,933
Net loss	(5,888,209)											(5,888,209)
Unrealized loss on short-term investments	(12,214)										(12,214)
Foreign currency translation adjustment	(3,097)										(3,097)
Balance at Jun. 30, 2022	$ 5,569,689				$ 11,046			$ 226,293,112			$ (15,710)	$ (220,718,759)
Balance, shares at Jun. 30, 2022					11,045,986