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<edgarSubmission xsi:schemaLocation="http://www.sec.gov/edgar/thirteenffiler eis_13F_Filer.xsd" xmlns="http://www.sec.gov/edgar/thirteenffiler" xmlns:ns1="http://www.sec.gov/edgar/common" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
    <submissionType>13F-NT</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>true</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0001169486</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>09-30-2019</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>09-30-2019</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>TOKIO MARINE HOLDINGS, INC.</name>
        <address>
          <ns1:street1>2-1 Marunouchi 1-chome,</ns1:street1>
          <ns1:city>Chiyoda-ku, Tokyo</ns1:city>
          <ns1:stateOrCountry>M0</ns1:stateOrCountry>
          <ns1:zipCode>100-1005</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F NOTICE</reportType>
      <form13FFileNumber>028-14109</form13FFileNumber>
      <otherManagersInfo>
        <otherManager>
          <cik>0001504169</cik>
          <form13FFileNumber>028-14025</form13FFileNumber>
          <name>TOKIO MARINE ASSET MANAGEMENT CO LTD</name>
        </otherManager>
        <otherManager>
          <cik>0000859139</cik>
          <form13FFileNumber>028-15443</form13FFileNumber>
          <name>DELPHI FINANCIAL GROUP, INC.</name>
        </otherManager>
        <otherManager>
          <cik>0000098561</cik>
          <form13FFileNumber>028-15859</form13FFileNumber>
          <name>TOKIO MARINE &amp; NICHIDO FIRE INSURANCE CO., LTD</name>
        </otherManager>
      </otherManagersInfo>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>Tokio Marine Asset Management Co., Ltd. ("TMAM") is a direct wholly-owned subsidiary of Tokio Marine Holdings, Inc. ("TMHD"). As a result of the corporate relationship between TMHD and TMAM, TMHD is deemed to share investment discretion with TMAM with respect to Section 13(f) securities over which TMAM exercises investment discretion. Delphi Financial Group, Inc. is a direct wholly-owned subsidiary of Tokio Marine &amp; Nichido Fire Insurance Co., Ltd. ("TMNF") and an indirect wholly-owned subsidiary of TMHD. TMNF is a direct wholly-owned subsidiary of TMHD.</additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>Kenichi Oka</name>
      <title>Manager</title>
      <phone>81-3-5223-1502</phone>
      <signature>/s/ Kenichi Oka</signature>
      <city>Tokyo</city>
      <stateOrCountry>M0</stateOrCountry>
      <signatureDate>10-29-2019</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount/>
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