X0203 3 2011-02-18 0 0000882796 BIOCRYST PHARMACEUTICALS INC BCRX 0001168465 LOWREY ROBERT S 4505 EMPEROR BLVD. SUITE 200 DURHAM NC 27703 1 Controller, PAO Emp. Stock Option (Right to Buy) 4.22 2012-02-07 2021-02-07 Common Stock 35000 D Options become exercisable at the rate of 25% after 1 year and then 1/48 per month thereafter until fully vested and exercisable after 48 months. /s/ Robert S. Lowrey 2011-02-28