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SHARE BASED COMPENSATION (Tables)
6 Months Ended
Jun. 30, 2016
SHARE BASED COMPENSATION [Abstract]  
Allocated share-based compensation expense
The following table summarizes share-based compensation related to stock options for the three and six months ended June 30:

   
Three Months Ended
 June 30,
  
Six Months Ended
 June 30,
 
   
2016
  
2015
  
2016
  
2015
 
  Research and development
 $323  $18,819  $8,993  $37,431 
  Selling, general and administrative
  17,825   51,019   37,022   107,755 
  Total share-based compensation expense
 $18,148  $69,838  $46,015  $145,186 
Stock option activity
The following table summarizes the stock options outstanding and the number of shares of Common Stock subject to exercise as of June 30, 2016 and the changes therein during the six months then ended:

   
Stock Options
  
Weighted Average Exercise Price per Share
 
Outstanding as of December 31, 2015
  1,664,573  $1.73 
Granted
  ---   --- 
Forfeited/cancelled
  (950,002) $1.27 
Exercised
  ---   --- 
Outstanding as of June 30, 2016
  714,571  $2.35 
Stock option grants outstanding and exercisable
The following table presents the stock option grants outstanding and exercisable as of June 30, 2016:

Options Outstanding
  
Options Exercisable
 
Stock Options Outstanding
  
Weighted Average Exercise Price per Share
  
Weighted Average Remaining Contractual Life in Years
  
Stock Options Exercisable
  
Weighted Average Exercise Price per Share
 
 422,500  $0.33   6.7   322,500  $0.33 
 240,000   1.15   8.2   75,000   1.15 
 52,071   24.20   1.1   52,071   24.20 
 714,571  $2.35   6.8   449,571  $3.23